4f8q
From Proteopedia
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{{STRUCTURE_4f8q| PDB=4f8q | SCENE= }} | {{STRUCTURE_4f8q| PDB=4f8q | SCENE= }} | ||
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===Crystal Structure of the Human BTN3A2 Ectodomain=== | ===Crystal Structure of the Human BTN3A2 Ectodomain=== | ||
| + | {{ABSTRACT_PUBMED_22846996}} | ||
| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/BT3A2_HUMAN BT3A2_HUMAN]] Plays a role in T-cell responses in the adaptive immune response. Inhibits the release of IFNG from activated T-cells.<ref>PMID:21918970</ref> <ref>PMID:22767497</ref> | ||
==About this Structure== | ==About this Structure== | ||
[[4f8q]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F8Q OCA]. | [[4f8q]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F8Q OCA]. | ||
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| + | ==Reference== | ||
| + | <ref group="xtra">PMID:022846996</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Adams, E J.]] | [[Category: Adams, E J.]] | ||
Revision as of 08:47, 19 June 2013
Contents |
Crystal Structure of the Human BTN3A2 Ectodomain
Template:ABSTRACT PUBMED 22846996
Function
[BT3A2_HUMAN] Plays a role in T-cell responses in the adaptive immune response. Inhibits the release of IFNG from activated T-cells.[1] [2]
About this Structure
4f8q is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Palakodeti A, Sandstrom A, Sundaresan L, Harly C, Nedellec S, Olive D, Scotet E, Bonneville M, Adams EJ. The molecular basis for modulation of human Vgamma9Vdelta2 T cell responses by CD277/butyrophilin-3 (BTN3A)-specific antibodies. J Biol Chem. 2012 Sep 21;287(39):32780-90. Epub 2012 Jul 30. PMID:22846996 doi:10.1074/jbc.M112.384354
- ↑ Messal N, Mamessier E, Sylvain A, Celis-Gutierrez J, Thibult ML, Chetaille B, Firaguay G, Pastor S, Guillaume Y, Wang Q, Hirsch I, Nunes JA, Olive D. Differential role for CD277 as a co-regulator of the immune signal in T and NK cells. Eur J Immunol. 2011 Dec;41(12):3443-54. doi: 10.1002/eji.201141404. Epub 2011 Nov, 3. PMID:21918970 doi:10.1002/eji.201141404
- ↑ Harly C, Guillaume Y, Nedellec S, Peigne CM, Monkkonen H, Monkkonen J, Li J, Kuball J, Adams EJ, Netzer S, Dechanet-Merville J, Leger A, Herrmann T, Breathnach R, Olive D, Bonneville M, Scotet E. Key implication of CD277/butyrophilin-3 (BTN3A) in cellular stress sensing by a major human gammadelta T-cell subset. Blood. 2012 Sep 13;120(11):2269-79. doi: 10.1182/blood-2012-05-430470. Epub 2012 , Jul 5. PMID:22767497 doi:10.1182/blood-2012-05-430470
