3raq
From Proteopedia
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{{STRUCTURE_3raq| PDB=3raq | SCENE= }} | {{STRUCTURE_3raq| PDB=3raq | SCENE= }} | ||
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===Dpo4 extension ternary complex with 3'-terminal primer C base opposite the 1-methylguanine (MG1) lesion=== | ===Dpo4 extension ternary complex with 3'-terminal primer C base opposite the 1-methylguanine (MG1) lesion=== | ||
| + | {{ABSTRACT_PUBMED_21645853}} | ||
| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/DPO4_SULSO DPO4_SULSO]] Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. It is involved in translesional synthesis.[HAMAP-Rule:MF_01113] | ||
==About this Structure== | ==About this Structure== | ||
[[3raq]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Sulfolobus_solfataricus Sulfolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RAQ OCA]. | [[3raq]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Sulfolobus_solfataricus Sulfolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RAQ OCA]. | ||
| - | == | + | ==Reference== |
| - | + | <ref group="xtra">PMID:021645853</ref><references group="xtra"/><references/> | |
[[Category: DNA-directed DNA polymerase]] | [[Category: DNA-directed DNA polymerase]] | ||
[[Category: Sulfolobus solfataricus]] | [[Category: Sulfolobus solfataricus]] | ||
Revision as of 09:11, 19 June 2013
Contents |
Dpo4 extension ternary complex with 3'-terminal primer C base opposite the 1-methylguanine (MG1) lesion
Template:ABSTRACT PUBMED 21645853
Function
[DPO4_SULSO] Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. It is involved in translesional synthesis.[HAMAP-Rule:MF_01113]
About this Structure
3raq is a 6 chain structure with sequence from Sulfolobus solfataricus. Full crystallographic information is available from OCA.
Reference
- Rechkoblit O, Delaney JC, Essigmann JM, Patel DJ. Implications for damage recognition during Dpo4-mediated mutagenic bypass of m1G and m3C lesions. Structure. 2011 Jun 8;19(6):821-32. doi: 10.1016/j.str.2011.03.020. PMID:21645853 doi:10.1016/j.str.2011.03.020
Categories: DNA-directed DNA polymerase | Sulfolobus solfataricus | Patel, D J. | Rechkoblit, O. | 1-methylguanine | Dna binding | Dna damage | Dna polymerase | Dna repair | Dna replication | Dna-binding | Dna-directed dna polymerase | Lesion bypass | Magnesium | Metal-binding | Nucleotidyltransferase | Protein-dna complex | Transferase | Transferase-dna complex | Y-family polymerase
