2gvf
From Proteopedia
(New page: 200px<br /><applet load="2gvf" size="350" color="white" frame="true" align="right" spinBox="true" caption="2gvf, resolution 2.50Å" /> '''HCV NS3-4A protease ...) |
|||
| Line 4: | Line 4: | ||
==Overview== | ==Overview== | ||
| - | Synthesis and HCV NS3 serine protease inhibitory activity of | + | Synthesis and HCV NS3 serine protease inhibitory activity of 4-hydroxyproline derived macrocyclic inhibitors and SAR around this macrocyclic core is described in this communication. X-ray structure of inhibitor 38 bound to the protease is discussed. |
==About this Structure== | ==About this Structure== | ||
| Line 15: | Line 15: | ||
[[Category: Arasappan, A.]] | [[Category: Arasappan, A.]] | ||
[[Category: Butkiewicz, N.]] | [[Category: Butkiewicz, N.]] | ||
| - | [[Category: Chen, K | + | [[Category: Chen, K X.]] |
[[Category: Girijavallabhan, V.]] | [[Category: Girijavallabhan, V.]] | ||
[[Category: Gu, H.]] | [[Category: Gu, H.]] | ||
[[Category: Madison, V.]] | [[Category: Madison, V.]] | ||
| - | [[Category: Njoroge, F | + | [[Category: Njoroge, F G.]] |
| - | [[Category: Parekh, T | + | [[Category: Parekh, T N.]] |
[[Category: Pichardo, J.]] | [[Category: Pichardo, J.]] | ||
[[Category: Prongay, A.]] | [[Category: Prongay, A.]] | ||
| Line 30: | Line 30: | ||
[[Category: protease]] | [[Category: protease]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:35:49 2008'' |
Revision as of 15:35, 21 February 2008
|
HCV NS3-4A protease domain complexed with a macrocyclic ketoamide inhibitor, SCH419021
Overview
Synthesis and HCV NS3 serine protease inhibitory activity of 4-hydroxyproline derived macrocyclic inhibitors and SAR around this macrocyclic core is described in this communication. X-ray structure of inhibitor 38 bound to the protease is discussed.
About this Structure
2GVF is a Protein complex structure of sequences from Hepatitis c virus with and as ligands. Full crystallographic information is available from OCA.
Reference
P2-P4 macrocyclic inhibitors of hepatitis C virus NS3-4A serine protease., Arasappan A, Njoroge FG, Chen KX, Venkatraman S, Parekh TN, Gu H, Pichardo J, Butkiewicz N, Prongay A, Madison V, Girijavallabhan V, Bioorg Med Chem Lett. 2006 Aug 1;16(15):3960-5. Epub 2006 May 30. PMID:16730985
Page seeded by OCA on Thu Feb 21 17:35:49 2008
