3o87
From Proteopedia
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| - | [[Image:3o87.png|left|200px]] | ||
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{{STRUCTURE_3o87| PDB=3o87 | SCENE= }} | {{STRUCTURE_3o87| PDB=3o87 | SCENE= }} | ||
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===Crystal structure of AmpC beta-lactamase in complex with a sulfonamide boronic acid inhibitor=== | ===Crystal structure of AmpC beta-lactamase in complex with a sulfonamide boronic acid inhibitor=== | ||
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{{ABSTRACT_PUBMED_20945905}} | {{ABSTRACT_PUBMED_20945905}} | ||
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| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/AMPC_ECOLI AMPC_ECOLI]] This protein is a serine beta-lactamase with a substrate specificity for cephalosporins. | ||
==About this Structure== | ==About this Structure== | ||
| - | [[3o87]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | [[3o87]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_k-12 Escherichia coli k-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O87 OCA]. |
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==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID:020945905</ref><references group="xtra"/> | + | <ref group="xtra">PMID:020945905</ref><references group="xtra"/><references/> |
[[Category: Beta-lactamase]] | [[Category: Beta-lactamase]] | ||
| - | [[Category: Escherichia coli]] | + | [[Category: Escherichia coli k-12]] |
[[Category: Eidam, O.]] | [[Category: Eidam, O.]] | ||
[[Category: Karpiak, J.]] | [[Category: Karpiak, J.]] | ||
Revision as of 09:32, 19 June 2013
Contents |
Crystal structure of AmpC beta-lactamase in complex with a sulfonamide boronic acid inhibitor
Template:ABSTRACT PUBMED 20945905
Function
[AMPC_ECOLI] This protein is a serine beta-lactamase with a substrate specificity for cephalosporins.
About this Structure
3o87 is a 2 chain structure with sequence from Escherichia coli k-12. Full crystallographic information is available from OCA.
Reference
- Eidam O, Romagnoli C, Caselli E, Babaoglu K, Pohlhaus DT, Karpiak J, Bonnet R, Shoichet BK, Prati F. Design, Synthesis, Crystal Structures, and Antimicrobial Activity of Sulfonamide Boronic Acids as beta-Lactamase Inhibitors. J Med Chem. 2010 Oct 14. PMID:20945905 doi:10.1021/jm101015z
