2gxb
From Proteopedia
| Line 4: | Line 4: | ||
==Overview== | ==Overview== | ||
| - | The A form RNA double helix can be transformed to a left-handed helix, called Z-RNA. Currently, little is known about the detailed structural | + | The A form RNA double helix can be transformed to a left-handed helix, called Z-RNA. Currently, little is known about the detailed structural features of Z-RNA or its involvement in cellular processes. The discovery that certain interferon-response proteins have domains that can stabilize Z-RNA as well as Z-DNA opens the way for the study of Z-RNA. Here, we present the 2.25 A crystal structure of the Zalpha domain of the RNA-editing enzyme ADAR1 (double-stranded RNA adenosine deaminase) complexed to a dUr(CG)(3) duplex RNA. The Z-RNA helix is associated with a unique solvent pattern that distinguishes it from the otherwise similar conformation of Z-DNA. Based on the structure, we propose a model suggesting how differences in solvation lead to two types of Z-RNA structures. The interaction of Zalpha with Z-RNA demonstrates how the interferon-induced isoform of ADAR1 could be targeted toward selected dsRNAs containing purine-pyrimidine repeats, possibly of viral origin. |
| + | |||
| + | ==Disease== | ||
| + | Known diseases associated with this structure: Dyschromatosis symmetrica hereditaria OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=601059 601059]] | ||
==About this Structure== | ==About this Structure== | ||
| Line 10: | Line 13: | ||
==Reference== | ==Reference== | ||
| - | A | + | A left-handed RNA double helix bound by the Z alpha domain of the RNA-editing enzyme ADAR1., Placido D, Brown BA 2nd, Lowenhaupt K, Rich A, Athanasiadis A, Structure. 2007 Apr;15(4):395-404. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17437712 17437712] |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| Line 23: | Line 26: | ||
[[Category: za]] | [[Category: za]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:36:16 2008'' |
Revision as of 15:36, 21 February 2008
|
Crystal Structure of The Za Domain bound to Z-RNA
Contents |
Overview
The A form RNA double helix can be transformed to a left-handed helix, called Z-RNA. Currently, little is known about the detailed structural features of Z-RNA or its involvement in cellular processes. The discovery that certain interferon-response proteins have domains that can stabilize Z-RNA as well as Z-DNA opens the way for the study of Z-RNA. Here, we present the 2.25 A crystal structure of the Zalpha domain of the RNA-editing enzyme ADAR1 (double-stranded RNA adenosine deaminase) complexed to a dUr(CG)(3) duplex RNA. The Z-RNA helix is associated with a unique solvent pattern that distinguishes it from the otherwise similar conformation of Z-DNA. Based on the structure, we propose a model suggesting how differences in solvation lead to two types of Z-RNA structures. The interaction of Zalpha with Z-RNA demonstrates how the interferon-induced isoform of ADAR1 could be targeted toward selected dsRNAs containing purine-pyrimidine repeats, possibly of viral origin.
Disease
Known diseases associated with this structure: Dyschromatosis symmetrica hereditaria OMIM:[601059]
About this Structure
2GXB is a Single protein structure of sequence from Homo sapiens with as ligand. Full crystallographic information is available from OCA.
Reference
A left-handed RNA double helix bound by the Z alpha domain of the RNA-editing enzyme ADAR1., Placido D, Brown BA 2nd, Lowenhaupt K, Rich A, Athanasiadis A, Structure. 2007 Apr;15(4):395-404. PMID:17437712
Page seeded by OCA on Thu Feb 21 17:36:16 2008
Categories: Homo sapiens | Single protein | Athanasiadis, A. | Placido, D. | Rich, A. | NA | Adar1 | Protein-rna complex | Rna editing | Z-rna | Za
