2gza
From Proteopedia
(New page: 200px<br /><applet load="2gza" size="450" color="white" frame="true" align="right" spinBox="true" caption="2gza, resolution 2.600Å" /> '''Crystal structure o...) |
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| - | [[Image:2gza.gif|left|200px]]<br /><applet load="2gza" size=" | + | [[Image:2gza.gif|left|200px]]<br /><applet load="2gza" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="2gza, resolution 2.600Å" /> | caption="2gza, resolution 2.600Å" /> | ||
'''Crystal structure of the VirB11 ATPase from the Brucella Suis type IV secretion system in complex with sulphate'''<br /> | '''Crystal structure of the VirB11 ATPase from the Brucella Suis type IV secretion system in complex with sulphate'''<br /> | ||
==Overview== | ==Overview== | ||
| - | VirB11 ATPases are hexameric assemblies that power type IV secretion | + | VirB11 ATPases are hexameric assemblies that power type IV secretion systems in bacteria. The hexamer of Brucella suis VirB11 (BsB11), like that of the Helicobacter pylori VirB11 (Hp0525), consists of a double ring structure formed by the N-terminal and C-terminal domains of each monomer. However, the monomer differs dramatically from that of Hp0525 by a large domain swap that leaves the hexameric assembly intact but profoundly alters the nucleotide-binding site and the interface between subunits. |
==About this Structure== | ==About this Structure== | ||
| - | 2GZA is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Brucella_suis Brucella suis] with SO4 as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/H(+)-transporting_two-sector_ATPase H(+)-transporting two-sector ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.14 3.6.3.14] Full crystallographic information is available from [http:// | + | 2GZA is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Brucella_suis Brucella suis] with <scene name='pdbligand=SO4:'>SO4</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/H(+)-transporting_two-sector_ATPase H(+)-transporting two-sector ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.14 3.6.3.14] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GZA OCA]. |
==Reference== | ==Reference== | ||
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[[Category: secretion]] | [[Category: secretion]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:36:37 2008'' |
Revision as of 15:36, 21 February 2008
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Crystal structure of the VirB11 ATPase from the Brucella Suis type IV secretion system in complex with sulphate
Overview
VirB11 ATPases are hexameric assemblies that power type IV secretion systems in bacteria. The hexamer of Brucella suis VirB11 (BsB11), like that of the Helicobacter pylori VirB11 (Hp0525), consists of a double ring structure formed by the N-terminal and C-terminal domains of each monomer. However, the monomer differs dramatically from that of Hp0525 by a large domain swap that leaves the hexameric assembly intact but profoundly alters the nucleotide-binding site and the interface between subunits.
About this Structure
2GZA is a Single protein structure of sequence from Brucella suis with as ligand. Active as H(+)-transporting two-sector ATPase, with EC number 3.6.3.14 Full crystallographic information is available from OCA.
Reference
A large domain swap in the VirB11 ATPase of Brucella suis leaves the hexameric assembly intact., Hare S, Bayliss R, Baron C, Waksman G, J Mol Biol. 2006 Jun 30;360(1):56-66. Epub 2006 May 11. PMID:16730027
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