We apologize for Proteopedia being slow to respond. For the past two years, a new implementation of Proteopedia has been being built. Soon, it will replace this 18-year old system. All existing content will be moved to the new system at a date that will be announced here.

4knz

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: {{STRUCTURE_4knz| PDB=4knz | SCENE= }} ===Thymidylate synthase ternary complex with dUMP AND CB3717=== {{ABSTRACT_PUBMED_23611499}} ==Function== [[http://www.uniprot.org/uniprot/TYSY...)
m (Protected "4knz" [edit=sysop:move=sysop])

Revision as of 13:19, 19 June 2013

Template:STRUCTURE 4knz

Contents

Thymidylate synthase ternary complex with dUMP AND CB3717

Template:ABSTRACT PUBMED 23611499

Function

[TYSY_ECOLI] Provides the sole de novo source of dTMP for DNA biosynthesis. This protein also binds to its mRNA thus repressing its own translation.

About this Structure

4knz is a 2 chain structure with sequence from Escherichia coli k-12. This structure supersedes the now removed PDB entries and 2g8o. Full crystallographic information is available from OCA.

Reference

  • Wang Z, Sapienza PJ, Abeysinghe T, Luzum C, Lee AL, Finer-Moore JS, Stroud RM, Kohen A. Mg2+ binds to the surface of thymidylate synthase and affects hydride transfer at the interior active site. J Am Chem Soc. 2013 Apr 23. PMID:23611499 doi:10.1021/ja400761x

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4knz"
Personal tools