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4fx8

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'''Unreleased structure'''
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{{STRUCTURE_4fx8| PDB=4fx8 | SCENE= }}
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===Crystal structure of the mutant Q185A.R203A of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with inhibitor BMP===
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{{ABSTRACT_PUBMED_23030629}}
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The entry 4fx8 is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/PYRF_METTH PYRF_METTH]] Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).[HAMAP-Rule:MF_01200_A]
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Authors: Fedorov, A.A., Fedorov, E.V., Desai, B., Gerlt, J.A., Almo, S.C.
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==About this Structure==
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[[4fx8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Methanothermobacter_thermautotrophicus_str._delta_h Methanothermobacter thermautotrophicus str. delta h]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FX8 OCA].
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Description: Crystal structure of the mutant Q185A.R203A of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with inhibitor BMP
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==Reference==
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<ref group="xtra">PMID:023030629</ref><references group="xtra"/><references/>
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[[Category: Methanothermobacter thermautotrophicus str. delta h]]
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[[Category: Orotidine-5'-phosphate decarboxylase]]
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[[Category: Almo, S C.]]
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[[Category: Desai, B.]]
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[[Category: Fedorov, A A.]]
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[[Category: Fedorov, E V.]]
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[[Category: Gerlt, J A.]]
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[[Category: Inhibitor bmp]]
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[[Category: Lyase-lyase inhibitor complex]]
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[[Category: Tim barrel]]

Revision as of 13:40, 19 June 2013

Template:STRUCTURE 4fx8

Contents

Crystal structure of the mutant Q185A.R203A of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with inhibitor BMP

Template:ABSTRACT PUBMED 23030629

Function

[PYRF_METTH] Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).[HAMAP-Rule:MF_01200_A]

About this Structure

4fx8 is a 2 chain structure with sequence from Methanothermobacter thermautotrophicus str. delta h. Full crystallographic information is available from OCA.

Reference

  • Desai BJ, Wood BM, Fedorov AA, Fedorov EV, Goryanova B, Amyes TL, Richard JP, Almo SC, Gerlt JA. Conformational Changes in Orotidine 5'-Monophosphate Decarboxylase: A Structure-Based Explanation for How the 5'-Phosphate Group Activates the Enzyme. Biochemistry. 2012 Oct 17. PMID:23030629 doi:10.1021/bi301188k

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OCA

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