4km5

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m (Protected "4km5" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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{{STRUCTURE_4km5| PDB=4km5 | SCENE= }}
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===X-ray crystal structure of human cyclic GMP-AMP synthase (cGAS)===
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{{ABSTRACT_PUBMED_23707061}}
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The entry 4km5 is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/CGAS_HUMAN CGAS_HUMAN]] Nucleotidyltransferase that catalyzes formation of cyclic GMP-AMP (cGAMP) from ATP and GTP and exhibits antiviral activity. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of DNA in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production.<ref>PMID:21478870</ref> <ref>PMID:23258413</ref>
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Authors: Kranzusch, P.J., Lee, A.S.Y., Berger, J.M., Doudna, J.A.
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==About this Structure==
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[[4km5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KM5 OCA].
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Description: New Protein Structure
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==Reference==
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<ref group="xtra">PMID:023707061</ref><references group="xtra"/><references/>
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[[Category: Homo sapiens]]
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[[Category: Berger, J M.]]
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[[Category: Doudna, J A.]]
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[[Category: Kranzusch, P J.]]
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[[Category: Lee, A S.Y.]]
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[[Category: Cytoplasmic]]
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[[Category: Dna]]
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[[Category: Dna sensor]]
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[[Category: Innate immunity]]
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[[Category: Nucleotidyl transferase]]
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[[Category: Transferase]]
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[[Category: Zinc finger]]

Revision as of 13:48, 19 June 2013

Template:STRUCTURE 4km5

Contents

X-ray crystal structure of human cyclic GMP-AMP synthase (cGAS)

Template:ABSTRACT PUBMED 23707061

Function

[CGAS_HUMAN] Nucleotidyltransferase that catalyzes formation of cyclic GMP-AMP (cGAMP) from ATP and GTP and exhibits antiviral activity. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of DNA in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production.[1] [2]

About this Structure

4km5 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Kranzusch PJ, Lee AS, Berger JM, Doudna JA. Structure of Human cGAS Reveals a Conserved Family of Second-Messenger Enzymes in Innate Immunity. Cell Rep. 2013 May 30;3(5):1362-8. doi: 10.1016/j.celrep.2013.05.008. Epub 2013, May 23. PMID:23707061 doi:10.1016/j.celrep.2013.05.008
  1. ↑ Schoggins JW, Wilson SJ, Panis M, Murphy MY, Jones CT, Bieniasz P, Rice CM. A diverse range of gene products are effectors of the type I interferon antiviral response. Nature. 2011 Apr 28;472(7344):481-5. doi: 10.1038/nature09907. Epub 2011 Apr 10. PMID:21478870 doi:10.1038/nature09907
  2. ↑ Sun L, Wu J, Du F, Chen X, Chen ZJ. Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway. Science. 2013 Feb 15;339(6121):786-91. doi: 10.1126/science.1232458. Epub 2012, Dec 20. PMID:23258413 doi:10.1126/science.1232458

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