4jnm

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m (Protected "4jnm" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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{{STRUCTURE_4jnm| PDB=4jnm | SCENE= }}
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===Discovery of Potent and Efficacious Urea-containing Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitors with Reduced CYP2C9 Inhibition Properties===
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{{ABSTRACT_PUBMED_23668988}}
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The entry 4jnm is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/NAMPT_HUMAN NAMPT_HUMAN]] Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway (By similarity).
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Authors: Gunzner-Toste, J., Zhao, G., Bauer, P., Baumeister, T., Buckmelter, A.J., Caligiuri, M., Clodfelter, K.H., Fu, B., Han, B., Ho, Y., Kley, N., Liederer, B., Lin, J., Mukadam, S., O'Brien, T., Reynolds, D.J., Sharma, G., Skelton, N., Smith, C.C., Oh, A., Wang, W., Wang, Z., Xiao, Y., Yuen, P., Zak, M., Zhang, L., Zheng, X., Bair, K.W., Dragovich, P.S.
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==About this Structure==
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[[4jnm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JNM OCA].
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Description: Discovery of Potent and Efficacious Urea-containing Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitors with Reduced CYP2C9 Inhibition Properties
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==Reference==
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<ref group="xtra">PMID:023668988</ref><references group="xtra"/><references/>
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[[Category: Homo sapiens]]
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[[Category: Nicotinamide phosphoribosyltransferase]]
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[[Category: Bair, K W.]]
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[[Category: Bauer, P.]]
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[[Category: Baumeister, T.]]
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[[Category: Brien, T O.]]
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[[Category: Buckmelter, A J.]]
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[[Category: Caligiuri, M.]]
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[[Category: Clodfelter, K H.]]
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[[Category: Dragovich, P S.]]
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[[Category: Fu, B.]]
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[[Category: Gunzner-Toste, J.]]
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[[Category: Han, B.]]
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[[Category: Ho, Y.]]
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[[Category: Kley, N.]]
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[[Category: Liederer, B.]]
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[[Category: Lin, J.]]
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[[Category: Mukadam, S.]]
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[[Category: Oh, A.]]
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[[Category: Reynolds, D J.]]
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[[Category: Sharma, G.]]
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[[Category: Skelton, N.]]
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[[Category: Smith, C C.]]
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[[Category: Wang, W.]]
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[[Category: Wang, Z.]]
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[[Category: Xiao, Y.]]
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[[Category: Yuen, P.]]
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[[Category: Zak, M.]]
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[[Category: Zhang, L.]]
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[[Category: Zhao, G.]]
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[[Category: Zheng, X.]]
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[[Category: Transferase-transferase inhibitor complex]]

Revision as of 13:57, 19 June 2013

Template:STRUCTURE 4jnm

Contents

Discovery of Potent and Efficacious Urea-containing Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitors with Reduced CYP2C9 Inhibition Properties

Template:ABSTRACT PUBMED 23668988

Function

[NAMPT_HUMAN] Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway (By similarity).

About this Structure

4jnm is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Gunzner-Toste J, Zhao G, Bauer P, Baumeister T, Buckmelter AJ, Caligiuri M, Clodfelter KH, Fu B, Han B, Ho YC, Kley N, Liang X, Liederer BM, Lin J, Mukadam S, O'Brien T, Oh A, Reynolds DJ, Sharma G, Skelton N, Smith CC, Sodhi J, Wang W, Wang Z, Xiao Y, Yuen PW, Zak M, Zhang L, Zheng X, Bair KW, Dragovich PS. Discovery of potent and efficacious urea-containing nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with reduced CYP2C9 inhibition properties. Bioorg Med Chem Lett. 2013 Jun 15;23(12):3531-8. doi: 10.1016/j.bmcl.2013.04.040., Epub 2013 Apr 25. PMID:23668988 doi:10.1016/j.bmcl.2013.04.040

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