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4jj8

From Proteopedia

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'''Unreleased structure'''
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{{STRUCTURE_4jj8| PDB=4jj8 | SCENE= }}
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===Caspase-3 specific unnatural amino acid peptides===
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{{ABSTRACT_PUBMED_23614665}}
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The entry 4jj8 is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/CASP7_HUMAN CASP7_HUMAN]] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Overexpression promotes programmed cell death.
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Authors: Vickers, C.J., Gonzalez-Paez, G.E., Wolan, D.W.
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==About this Structure==
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[[4jj8]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JJ8 OCA].
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Description: Caspase-3 specific unnatural amino acid peptides
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==Reference==
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<ref group="xtra">PMID:023614665</ref><references group="xtra"/><references/>
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[[Category: Caspase-7]]
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[[Category: Homo sapiens]]
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[[Category: Gonzalez-Paez, G E.]]
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[[Category: Vickers, C J.]]
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[[Category: Wolan, D W.]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Protease]]

Revision as of 13:58, 19 June 2013

Template:STRUCTURE 4jj8

Contents

Caspase-3 specific unnatural amino acid peptides

Template:ABSTRACT PUBMED 23614665

Function

[CASP7_HUMAN] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Overexpression promotes programmed cell death.

About this Structure

4jj8 is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Vickers CJ, Gonzalez-Paez GE, Wolan DW. Selective Detection of Caspase-3 versus Caspase-7 Using Activity-Based Probes with Key Unnatural Amino Acids. ACS Chem Biol. 2013 May 3. PMID:23614665 doi:10.1021/cb400209w

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