4jj8

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
'''Unreleased structure'''
+
{{STRUCTURE_4jj8| PDB=4jj8 | SCENE= }}
 +
===Caspase-3 specific unnatural amino acid peptides===
 +
{{ABSTRACT_PUBMED_23614665}}
-
The entry 4jj8 is ON HOLD
+
==Function==
 +
[[http://www.uniprot.org/uniprot/CASP7_HUMAN CASP7_HUMAN]] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Overexpression promotes programmed cell death.
-
Authors: Vickers, C.J., Gonzalez-Paez, G.E., Wolan, D.W.
+
==About this Structure==
 +
[[4jj8]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JJ8 OCA].
-
Description: Caspase-3 specific unnatural amino acid peptides
+
==Reference==
 +
<ref group="xtra">PMID:023614665</ref><references group="xtra"/><references/>
 +
[[Category: Caspase-7]]
 +
[[Category: Homo sapiens]]
 +
[[Category: Gonzalez-Paez, G E.]]
 +
[[Category: Vickers, C J.]]
 +
[[Category: Wolan, D W.]]
 +
[[Category: Hydrolase-hydrolase inhibitor complex]]
 +
[[Category: Protease]]

Revision as of 13:58, 19 June 2013

Template:STRUCTURE 4jj8

Contents

Caspase-3 specific unnatural amino acid peptides

Template:ABSTRACT PUBMED 23614665

Function

[CASP7_HUMAN] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Overexpression promotes programmed cell death.

About this Structure

4jj8 is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Vickers CJ, Gonzalez-Paez GE, Wolan DW. Selective Detection of Caspase-3 versus Caspase-7 Using Activity-Based Probes with Key Unnatural Amino Acids. ACS Chem Biol. 2013 May 3. PMID:23614665 doi:10.1021/cb400209w

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4jj8"
Personal tools