4bds

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m (Protected "4bds" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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{{STRUCTURE_4bds| PDB=4bds | SCENE= }}
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===Human butyrylcholinesterase in complex with tacrine===
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{{ABSTRACT_PUBMED_23679855}}
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The entry 4bds is ON HOLD until Paper Publication
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==Disease==
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[[http://www.uniprot.org/uniprot/CHLE_HUMAN CHLE_HUMAN]] Defects in BCHE are the cause of butyrylcholinesterase deficiency (BChE deficiency) [MIM:[http://omim.org/entry/177400 177400]]. BChE deficiency is a metabolic disorder characterized by prolonged apnoea after the use of certain anesthetic drugs, including the muscle relaxants succinylcholine or mivacurium and other ester local anesthetics. The duration of the prolonged apnoea varies significantly depending on the extent of the enzyme deficiency. BChE deficiency is a multifactorial disorder. The hereditary condition is transmitted as an autosomal recessive trait.
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Authors: Nachon, F., Carletti, E., Ronco, C., Trovaslet, M., Nicolet, Y., Jean, L., Renard, P.-Y.
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==Function==
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[[http://www.uniprot.org/uniprot/CHLE_HUMAN CHLE_HUMAN]] Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters.<ref>PMID:19542320</ref> <ref>PMID:19452557</ref>
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Description: Human butyrylcholinesterase in complex with tacrine
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==About this Structure==
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[[4bds]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BDS OCA].
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==Reference==
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<ref group="xtra">PMID:023679855</ref><references group="xtra"/><references/>
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[[Category: Cholinesterase]]
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[[Category: Homo sapiens]]
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[[Category: Carletti, E.]]
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[[Category: Jean, L.]]
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[[Category: Nachon, F.]]
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[[Category: Nicolet, Y.]]
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[[Category: Renard, P Y.]]
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[[Category: Ronco, C.]]
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[[Category: Trovaslet, M.]]
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[[Category: Alpha-beta hydrolase]]
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[[Category: Hydrolase]]
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[[Category: Inhibitior]]
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[[Category: Nerve transmission]]

Revision as of 13:58, 19 June 2013

Template:STRUCTURE 4bds

Contents

Human butyrylcholinesterase in complex with tacrine

Template:ABSTRACT PUBMED 23679855

Disease

[CHLE_HUMAN] Defects in BCHE are the cause of butyrylcholinesterase deficiency (BChE deficiency) [MIM:177400]. BChE deficiency is a metabolic disorder characterized by prolonged apnoea after the use of certain anesthetic drugs, including the muscle relaxants succinylcholine or mivacurium and other ester local anesthetics. The duration of the prolonged apnoea varies significantly depending on the extent of the enzyme deficiency. BChE deficiency is a multifactorial disorder. The hereditary condition is transmitted as an autosomal recessive trait.

Function

[CHLE_HUMAN] Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters.[1] [2]

About this Structure

4bds is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Nachon F, Carletti E, Ronco C, Trovaslet M, Nicolet Y, Jean L, Renard PY. Crystal Structures of Human Cholinesterases in Complex with Huprine W and Tacrine: Elements of Specificity for Anti-Alzheimer's Drugs Targeting Acetyl- and Butyrylcholinesterase. Biochem J. 2013 May 17. PMID:23679855 doi:10.1042/BJ20130013
  1. ↑ Chilukuri N, Duysen EG, Parikh K, diTargiani R, Doctor BP, Lockridge O, Saxena A. Adenovirus-transduced human butyrylcholinesterase in mouse blood functions as a bioscavenger of chemical warfare nerve agents. Mol Pharmacol. 2009 Sep;76(3):612-7. doi: 10.1124/mol.109.055665. Epub 2009 Jun, 19. PMID:19542320 doi:10.1124/mol.109.055665
  2. ↑ Amitay M, Shurki A. The structure of G117H mutant of butyrylcholinesterase: nerve agents scavenger. Proteins. 2009 Nov 1;77(2):370-7. doi: 10.1002/prot.22442. PMID:19452557 doi:10.1002/prot.22442

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