4jje

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m (Protected "4jje" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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{{STRUCTURE_4jje| PDB=4jje | SCENE= }}
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===Caspase-3 specific unnatural amino acid peptides===
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{{ABSTRACT_PUBMED_23614665}}
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The entry 4jje is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/CASP3_HUMAN CASP3_HUMAN]] Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.<ref>PMID:7596430</ref> <ref>PMID:21357690</ref>
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Authors: Vickers, C.J., Gonzalez-Paez, G.E., Wolan, D.W.
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==About this Structure==
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[[4jje]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JJE OCA].
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Description: Caspase-3 specific unnatural amino acid peptides
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==Reference==
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<ref group="xtra">PMID:023614665</ref><references group="xtra"/><references/>
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[[Category: Caspase-3]]
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[[Category: Homo sapiens]]
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[[Category: Gonzalez-Paez, G E.]]
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[[Category: Vickers, C J.]]
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[[Category: Wolan, D W.]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Protease]]

Revision as of 14:04, 19 June 2013

Template:STRUCTURE 4jje

Contents

Caspase-3 specific unnatural amino acid peptides

Template:ABSTRACT PUBMED 23614665

Function

[CASP3_HUMAN] Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.[1] [2]

About this Structure

4jje is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Vickers CJ, Gonzalez-Paez GE, Wolan DW. Selective Detection of Caspase-3 versus Caspase-7 Using Activity-Based Probes with Key Unnatural Amino Acids. ACS Chem Biol. 2013 May 3. PMID:23614665 doi:10.1021/cb400209w
  1. ↑ Nicholson DW, Ali A, Thornberry NA, Vaillancourt JP, Ding CK, Gallant M, Gareau Y, Griffin PR, Labelle M, Lazebnik YA, et al.. Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis. Nature. 1995 Jul 6;376(6535):37-43. PMID:7596430 doi:http://dx.doi.org/10.1038/376037a0
  2. ↑ Cabrera JR, Bouzas-Rodriguez J, Tauszig-Delamasure S, Mehlen P. RET modulates cell adhesion via its cleavage by caspase in sympathetic neurons. J Biol Chem. 2011 Apr 22;286(16):14628-38. doi: 10.1074/jbc.M110.195461. Epub, 2011 Feb 28. PMID:21357690 doi:10.1074/jbc.M110.195461

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