4hl8

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'''Unreleased structure'''
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{{STRUCTURE_4hl8| PDB=4hl8 | SCENE= }}
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===Re-refinement of the vault ribonucleoprotein particle===
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{{ABSTRACT_PUBMED_19150846}}
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The entry 4hl8 is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/MVP_RAT MVP_RAT]] Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates INFG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases (By similarity).
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Authors: Casanas, A., Querol-Audi, J., Guerra, P., Pous, J., Tanaka, H., Tsukihara, T., Verdaguer, V., Fita, I.
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==About this Structure==
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[[4hl8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HL8 OCA].
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Description: Re-refinement of the vault ribonucleoprotein particle
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==Reference==
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<ref group="xtra">PMID:019150846</ref><references group="xtra"/><references/>
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[[Category: Rattus norvegicus]]
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[[Category: Casanas, A.]]
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[[Category: Fita, I.]]
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[[Category: Guerra, P.]]
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[[Category: Pous, J.]]
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[[Category: Querol-Audi, J.]]
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[[Category: Tanaka, H.]]
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[[Category: Tsukihara, T.]]
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[[Category: Verdaguer, V.]]
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[[Category: 9 repeat domain]]
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[[Category: Cytoplasmic]]
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[[Category: Protein-protein complex]]
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[[Category: Ribonucleoprotein]]
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[[Category: Structural protein]]

Revision as of 14:05, 19 June 2013

Template:STRUCTURE 4hl8

Contents

Re-refinement of the vault ribonucleoprotein particle

Template:ABSTRACT PUBMED 19150846

Function

[MVP_RAT] Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates INFG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases (By similarity).

About this Structure

4hl8 is a 1 chain structure with sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

  • Tanaka H, Kato K, Yamashita E, Sumizawa T, Zhou Y, Yao M, Iwasaki K, Yoshimura M, Tsukihara T. The structure of rat liver vault at 3.5 angstrom resolution. Science. 2009 Jan 16;323(5912):384-8. PMID:19150846 doi:http://dx.doi.org/323/5912/384

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OCA

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