4fvd

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'''Unreleased structure'''
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{{STRUCTURE_4fvd| PDB=4fvd | SCENE= }}
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===Crystal structure of EV71 2A proteinase C110A mutant in complex with substrate===
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{{ABSTRACT_PUBMED_23616646}}
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The entry 4fvd is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/A9XG43_9ENTO A9XG43_9ENTO]] Protein 2C associates with and induces structural rearrangements of intracellular membranes. It displays RNA-binding, nucleotide binding and NTPase activities (By similarity).[SAAS:SAAS000199_004_016611] Protein 3C is a cysteine protease that generates mature viral proteins from the precursor polyprotein. In addition to its proteolytic activity, it binds to viral RNA, and thus influences viral genome replication. RNA and substrate bind co-operatively to the protease (By similarity).[SAAS:SAAS000199_004_042266] RNA-directed RNA polymerase 3D-POL replicates genomic and antigenomic RNA by recognizing replications specific signals (By similarity).[SAAS:SAAS000199_004_010047]
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Authors: Cai, Q., Muhammad, Y., Liu, W., Gao, Z., Peng, X., Cai, Y., Wu, C., Zheng, Q., Li, J., Lin, T.
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==About this Structure==
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[[4fvd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterovirus_a71 Enterovirus a71]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FVD OCA].
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Description: Crystal structure of EV71 2A proteinase C110A mutant in complex with substrate
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==Reference==
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<ref group="xtra">PMID:023616646</ref><references group="xtra"/><references/>
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[[Category: Enterovirus a71]]
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[[Category: Picornain 2A]]
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[[Category: Cai, Q.]]
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[[Category: Cai, Y.]]
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[[Category: Gao, Z.]]
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[[Category: Li, J.]]
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[[Category: Lin, T.]]
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[[Category: Liu, W.]]
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[[Category: Muhammad, Y.]]
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[[Category: Peng, X.]]
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[[Category: Wu, C.]]
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[[Category: Zheng, Q.]]
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[[Category: Cysteine proteinase]]
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[[Category: Hydrolase]]
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[[Category: Hydrolase-hydrolase substrate complex]]

Revision as of 15:06, 19 June 2013

Template:STRUCTURE 4fvd

Contents

Crystal structure of EV71 2A proteinase C110A mutant in complex with substrate

Template:ABSTRACT PUBMED 23616646

Function

[A9XG43_9ENTO] Protein 2C associates with and induces structural rearrangements of intracellular membranes. It displays RNA-binding, nucleotide binding and NTPase activities (By similarity).[SAAS:SAAS000199_004_016611] Protein 3C is a cysteine protease that generates mature viral proteins from the precursor polyprotein. In addition to its proteolytic activity, it binds to viral RNA, and thus influences viral genome replication. RNA and substrate bind co-operatively to the protease (By similarity).[SAAS:SAAS000199_004_042266] RNA-directed RNA polymerase 3D-POL replicates genomic and antigenomic RNA by recognizing replications specific signals (By similarity).[SAAS:SAAS000199_004_010047]

About this Structure

4fvd is a 2 chain structure with sequence from Enterovirus a71. Full crystallographic information is available from OCA.

Reference

  • Cai Q, Yameen M, Liu W, Gao Z, Li Y, Peng X, Cai Y, Wu C, Zheng Q, Li J, Lin T. Conformational Plasticity of 2A Proteinase from Enterovirus 71. J Virol. 2013 Apr 24. PMID:23616646 doi:10.1128/JVI.03541-12

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OCA

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