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4ini

From Proteopedia

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'''Unreleased structure'''
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{{STRUCTURE_4ini| PDB=4ini | SCENE= }}
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===Human Histidine Triad Nucleotide Binding Protein 2 with Bound AMP===
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{{ABSTRACT_PUBMED_23659632}}
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The entry 4ini is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/HINT2_HUMAN HINT2_HUMAN]] Hydrolase probably involved in steroid biosynthesis. May play a role in apoptosis. Has adenosine phosphoramidase activity.<ref>PMID:16762638</ref> <ref>PMID:18653718</ref>
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Authors: Maize, K.M., Wagner, C.R., Finzel, B.C.
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==About this Structure==
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[[4ini]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptomyces_aureorectus Streptomyces aureorectus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4INI OCA].
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Description: Human Histidine Triad Nucleotide Binding Protein 2 with Bound AMP
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==Reference==
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<ref group="xtra">PMID:023659632</ref><references group="xtra"/><references/>
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[[Category: Streptomyces aureorectus]]
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[[Category: Finzel, B C.]]
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[[Category: Maize, K M.]]
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[[Category: Wagner, C R.]]
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[[Category: Hint]]
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[[Category: Histidine triad]]
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[[Category: Hit]]
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[[Category: Hydrolase]]
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[[Category: Phosphoramidase]]

Revision as of 15:31, 19 June 2013

Template:STRUCTURE 4ini

Contents

Human Histidine Triad Nucleotide Binding Protein 2 with Bound AMP

Template:ABSTRACT PUBMED 23659632

Function

[HINT2_HUMAN] Hydrolase probably involved in steroid biosynthesis. May play a role in apoptosis. Has adenosine phosphoramidase activity.[1] [2]

About this Structure

4ini is a 2 chain structure with sequence from Streptomyces aureorectus. Full crystallographic information is available from OCA.

Reference

  • Maize KM, Wagner CR, Finzel BC. Structural characterization of human histidine triad nucleotide binding protein 2 (hHint2), a member of the histidine triad (HIT) superfamily. FEBS J. 2013 May 10. doi: 10.1111/febs.12330. PMID:23659632 doi:10.1111/febs.12330
  1. ↑ Martin J, Magnino F, Schmidt K, Piguet AC, Lee JS, Semela D, St-Pierre MV, Ziemiecki A, Cassio D, Brenner C, Thorgeirsson SS, Dufour JF. Hint2, a mitochondrial apoptotic sensitizer down-regulated in hepatocellular carcinoma. Gastroenterology. 2006 Jun;130(7):2179-88. PMID:16762638 doi:10.1053/j.gastro.2006.03.024
  2. ↑ Lenglet S, Antigny F, Vetterli L, Dufour JF, Rossier MF. Hint2 is expressed in the mitochondria of H295R cells and is involved in steroidogenesis. Endocrinology. 2008 Nov;149(11):5461-9. doi: 10.1210/en.2008-0400. Epub 2008 Jul , 24. PMID:18653718 doi:10.1210/en.2008-0400

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