4k5l

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m (Protected "4k5l" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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{{STRUCTURE_4k5l| PDB=4k5l | SCENE= }}
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===Phosphonic Arginine Mimetics as Inhibitors of the M1 Aminopeptidases from Plasmodium falciparum===
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{{ABSTRACT_PUBMED_23713488}}
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The entry 4k5l is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/AMP1_PLAFQ AMP1_PLAFQ]] Displays aminopeptidase activity with a broad substrate specificity. Preferentially hydrolyzes L-Lys-AMC but also shows strong activity against L-Ala-AMC, L-Arg-AMC and L-Leu-AMC.<ref>PMID:12166515</ref> <ref>PMID:19196988</ref>
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Authors: McGowan, S.
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==About this Structure==
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[[4k5l]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum_fcb1/columbia Plasmodium falciparum fcb1/columbia]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K5L OCA].
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Description: Phosphonic Arginine Mimetics as Inhibitors of the M1 Aminopeptidases from Plasmodium falciparum
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==Reference==
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<ref group="xtra">PMID:023713488</ref><references group="xtra"/><references/>
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[[Category: Plasmodium falciparum fcb1/columbia]]
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[[Category: McGowan, S.]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: M1 alanyl-aminopeptidase]]
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[[Category: Protease]]

Revision as of 15:33, 19 June 2013

Template:STRUCTURE 4k5l

Contents

Phosphonic Arginine Mimetics as Inhibitors of the M1 Aminopeptidases from Plasmodium falciparum

Template:ABSTRACT PUBMED 23713488

Function

[AMP1_PLAFQ] Displays aminopeptidase activity with a broad substrate specificity. Preferentially hydrolyzes L-Lys-AMC but also shows strong activity against L-Ala-AMC, L-Arg-AMC and L-Leu-AMC.[1] [2]

About this Structure

4k5l is a 1 chain structure with sequence from Plasmodium falciparum fcb1/columbia. Full crystallographic information is available from OCA.

Reference

  • Kannan Sivaraman K, Paiardini A, Sienczyk M, Ruggeri C, Oellig CA, Dalton JP, Scammells PJ, Drag M, McGowan S. Synthesis and Structure-Activity Relationships of Phosphonic Arginine Mimetics as Inhibitors of the M1 and M17 Aminopeptidases from Plasmodium falciparum J Med Chem. 2013 May 28. PMID:23713488 doi:10.1021/jm4005972
  1. ↑ Allary M, Schrevel J, Florent I. Properties, stage-dependent expression and localization of Plasmodium falciparum M1 family zinc-aminopeptidase. Parasitology. 2002 Jul;125(Pt 1):1-10. PMID:12166515
  2. ↑ McGowan S, Porter CJ, Lowther J, Stack CM, Golding SJ, Skinner-Adams TS, Trenholme KR, Teuscher F, Donnelly SM, Grembecka J, Mucha A, Kafarski P, Degori R, Buckle AM, Gardiner DL, Whisstock JC, Dalton JP. Structural basis for the inhibition of the essential Plasmodium falciparum M1 neutral aminopeptidase. Proc Natl Acad Sci U S A. 2009 Feb 5. PMID:19196988

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