2m6n

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m (Protected "2m6n" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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{{STRUCTURE_2m6n| PDB=2m6n | SCENE= }}
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===3D solution structure of EMI1 (Early Mitotic Inhibitor 1)===
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{{ABSTRACT_PUBMED_23708605}}
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The entry 2m6n is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/FBX5_HUMAN FBX5_HUMAN]] Regulates progression through early mitosis by inhibiting the anaphase promoting complex/cyclosome (APC). Binds to the APC activators CDC20 and FZR1/CDH1 to prevent APC activation. Can also bind directly to the APC to inhibit substrate-binding.<ref>PMID:11988738</ref> <ref>PMID:16921029</ref>
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Authors: Frye, J.J., Brown, N.G., Petzold, G., Watson, E.R., Royappa, G.R., Nourse, A., Jarvis, M., Kriwacki, R.W., Peters, J., Stark, H., Schulman, B.A.
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==About this Structure==
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[[2m6n]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M6N OCA].
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Description: ZINC Binding Domain
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==Reference==
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<ref group="xtra">PMID:023708605</ref><references group="xtra"/><references/>
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[[Category: Homo sapiens]]
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[[Category: Brown, N G.]]
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[[Category: Frye, J J.]]
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[[Category: Jarvis, M.]]
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[[Category: Kriwacki, R W.]]
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[[Category: Nourse, A.]]
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[[Category: Peters, J.]]
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[[Category: Petzold, G.]]
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[[Category: Royappa, G R.]]
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[[Category: Schulman, B A.]]
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[[Category: Stark, H.]]
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[[Category: Watson, E R.]]
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[[Category: Apc]]
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[[Category: Cell cycle]]
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[[Category: E3 ligase]]
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[[Category: Emi1]]
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[[Category: Zbr]]

Revision as of 15:34, 19 June 2013

Template:STRUCTURE 2m6n

Contents

3D solution structure of EMI1 (Early Mitotic Inhibitor 1)

Template:ABSTRACT PUBMED 23708605

Function

[FBX5_HUMAN] Regulates progression through early mitosis by inhibiting the anaphase promoting complex/cyclosome (APC). Binds to the APC activators CDC20 and FZR1/CDH1 to prevent APC activation. Can also bind directly to the APC to inhibit substrate-binding.[1] [2]

About this Structure

2m6n is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

  • Frye JJ, Brown NG, Petzold G, Watson ER, Grace CR, Nourse A, Jarvis MA, Kriwacki RW, Peters JM, Stark H, Schulman BA. Electron microscopy structure of human APC/C-EMI1 reveals multimodal mechanism of E3 ligase shutdown. Nat Struct Mol Biol. 2013 May 26. doi: 10.1038/nsmb.2593. PMID:23708605 doi:10.1038/nsmb.2593
  1. ↑ Hsu JY, Reimann JD, Sorensen CS, Lukas J, Jackson PK. E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1). Nat Cell Biol. 2002 May;4(5):358-66. PMID:11988738 doi:10.1038/ncb785
  2. ↑ Miller JJ, Summers MK, Hansen DV, Nachury MV, Lehman NL, Loktev A, Jackson PK. Emi1 stably binds and inhibits the anaphase-promoting complex/cyclosome as a pseudosubstrate inhibitor. Genes Dev. 2006 Sep 1;20(17):2410-20. Epub 2006 Aug 18. PMID:16921029 doi:gad.1454006

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