3d1b

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[[Image:3d1b.png|left|200px]]
 
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{{STRUCTURE_3d1b| PDB=3d1b | SCENE= }}
{{STRUCTURE_3d1b| PDB=3d1b | SCENE= }}
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===Tetragonal crystal structure of Tas3 C-terminal alpha motif===
===Tetragonal crystal structure of Tas3 C-terminal alpha motif===
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{{ABSTRACT_PUBMED_19394293}}
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{{ABSTRACT_PUBMED_019394293}}
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==Function==
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[[http://www.uniprot.org/uniprot/TAS3_SCHPO TAS3_SCHPO]] Has a role in the RNA interference (RNAi) pathway which is important for heterochromatin formation and accurate chromosome segregation. A member of the RNA-induced transcriptional silencing (RITS) complex which is involved in the biosynthesis of dsRNA from primer siRNAs provided by the RNA-directed RNA polymerase (RDRC) complex.<ref>PMID:15607976</ref> <ref>PMID:14704433</ref>
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:019394293</ref><references group="xtra"/>
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<ref group="xtra">PMID:019394293</ref><references group="xtra"/><references/>
[[Category: Schizosaccharomyces pombe]]
[[Category: Schizosaccharomyces pombe]]
[[Category: Li, H.]]
[[Category: Li, H.]]

Revision as of 15:37, 19 June 2013

Template:STRUCTURE 3d1b

Contents

Tetragonal crystal structure of Tas3 C-terminal alpha motif

Template:ABSTRACT PUBMED 19394293

Function

[TAS3_SCHPO] Has a role in the RNA interference (RNAi) pathway which is important for heterochromatin formation and accurate chromosome segregation. A member of the RNA-induced transcriptional silencing (RITS) complex which is involved in the biosynthesis of dsRNA from primer siRNAs provided by the RNA-directed RNA polymerase (RDRC) complex.[1] [2]

About this Structure

3d1b is a 3 chain structure with sequence from Schizosaccharomyces pombe. Full crystallographic information is available from OCA.

Reference

  • Li H, Motamedi MR, Yip CK, Wang Z, Walz T, Patel DJ, Moazed D. An alpha motif at Tas3 C terminus mediates RITS cis spreading and promotes heterochromatic gene silencing. Mol Cell. 2009 Apr 24;34(2):155-67. PMID:19394293 doi:10.1016/j.molcel.2009.02.032
  1. ↑ Motamedi MR, Verdel A, Colmenares SU, Gerber SA, Gygi SP, Moazed D. Two RNAi complexes, RITS and RDRC, physically interact and localize to noncoding centromeric RNAs. Cell. 2004 Dec 17;119(6):789-802. PMID:15607976 doi:10.1016/j.cell.2004.11.034
  2. ↑ Verdel A, Jia S, Gerber S, Sugiyama T, Gygi S, Grewal SI, Moazed D. RNAi-mediated targeting of heterochromatin by the RITS complex. Science. 2004 Jan 30;303(5658):672-6. Epub 2004 Jan 2. PMID:14704433 doi:10.1126/science.1093686

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