4fzb

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'''Unreleased structure'''
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{{STRUCTURE_4fzb| PDB=4fzb | SCENE= }}
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===Structure of thymidylate synthase ThyX complexed to a new inhibitor===
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{{ABSTRACT_PUBMED_23155486}}
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The entry 4fzb is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/THYX_PBCV1 THYX_PBCV1]] Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity).
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Authors: Basta, T., Boum, Y., Briffotaux, J., Becker, H.F., Lamarre-Jouenne, I., Lambry, J.C., Skouloubris, S., Liebl, U., van Tilbeurgh, H., Graille, M., Myllylkallio, H.
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==About this Structure==
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[[4fzb]] is a 16 chain structure with sequence from [http://en.wikipedia.org/wiki/Paramecium_bursaria_chlorella_virus_1 Paramecium bursaria chlorella virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FZB OCA].
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Description: Enzyme-inhibitor complex
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==Reference==
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<ref group="xtra">PMID:023155486</ref><references group="xtra"/><references/>
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[[Category: Paramecium bursaria chlorella virus 1]]
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[[Category: Basta, T.]]
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[[Category: Becker, H F.]]
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[[Category: Boum, Y.]]
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[[Category: Briffotaux, J.]]
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[[Category: Graille, M.]]
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[[Category: Lamarre-Jouenne, I.]]
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[[Category: Lambry, J C.]]
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[[Category: Liebl, U.]]
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[[Category: Myllylkallio, H.]]
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[[Category: Skouloubris, S.]]
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[[Category: Tilbeurgh, H van.]]
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[[Category: Fad-dependent thymidylate synthase]]
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[[Category: Homotetramer]]
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[[Category: Transferase-transferase inhibitor complex]]

Revision as of 15:38, 19 June 2013

Template:STRUCTURE 4fzb

Contents

Structure of thymidylate synthase ThyX complexed to a new inhibitor

Template:ABSTRACT PUBMED 23155486

Function

[THYX_PBCV1] Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity).

About this Structure

4fzb is a 16 chain structure with sequence from Paramecium bursaria chlorella virus 1. Full crystallographic information is available from OCA.

Reference

  • Basta T, Boum Y, Briffotaux J, Becker HF, Lamarre-Jouenne I, Lambry JC, Skouloubris S, Liebl U, Graille M, van Tilbeurgh H, Myllykallio H. Mechanistic and structural basis for inhibition of thymidylate synthase ThyX. Open Biol. 2012 Oct;2(10):120120. doi: 10.1098/rsob.120120. PMID:23155486 doi:10.1098/rsob.120120

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OCA

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