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4j19

From Proteopedia

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'''Unreleased structure'''
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{{STRUCTURE_4j19| PDB=4j19 | SCENE= }}
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===Structure of a novel telomere repeat binding protein bound to DNA===
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{{ABSTRACT_PUBMED_23685356}}
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The entry 4j19 is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/HMBX1_HUMAN HMBX1_HUMAN]] Transcription factor. Isoform 1 acts as a transcriptional repressor. Isoform 4 has very low activity as a transcriptional repressor.<ref>PMID:16825764</ref> <ref>PMID:19757162</ref>
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Authors: Kappei, D., Butter, F., Benda, C., Scheibe, M., Draskovic, I., Stevense, M., Lopes Novo, C., Basquin, C., Krastev, D.B., Kittler, R., Jessberger, R., Londono-Vallejo, A.J., Mann, M., Buchholz, F.
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==About this Structure==
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[[4j19]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J19 OCA].
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Description: Structure of a novel telomere repeat binding protein bound to DNA
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==Reference==
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<ref group="xtra">PMID:023685356</ref><references group="xtra"/><references/>
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[[Category: Homo sapiens]]
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[[Category: Basquin, C.]]
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[[Category: Benda, C.]]
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[[Category: Buchholz, F.]]
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[[Category: Butter, F.]]
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[[Category: Draskovic, I.]]
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[[Category: Jessberger, R.]]
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[[Category: Kappei, D.]]
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[[Category: Kittler, R.]]
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[[Category: Krastev, D B.]]
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[[Category: Londono-Vallejo, A J.]]
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[[Category: Mann, M.]]
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[[Category: Novo, C Lopes.]]
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[[Category: Scheibe, M.]]
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[[Category: Stevense, M.]]
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[[Category: Telomere repeat binding]]
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[[Category: Telomeric dna]]
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[[Category: Transcription-dna complex]]

Revision as of 15:39, 19 June 2013

Template:STRUCTURE 4j19

Contents

Structure of a novel telomere repeat binding protein bound to DNA

Template:ABSTRACT PUBMED 23685356

Function

[HMBX1_HUMAN] Transcription factor. Isoform 1 acts as a transcriptional repressor. Isoform 4 has very low activity as a transcriptional repressor.[1] [2]

About this Structure

4j19 is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Kappei D, Butter F, Benda C, Scheibe M, Draskovic I, Stevense M, Novo CL, Basquin C, Araki M, Araki K, Krastev DB, Kittler R, Jessberger R, Londono-Vallejo JA, Mann M, Buchholz F. HOT1 is a mammalian direct telomere repeat-binding protein contributing to telomerase recruitment. EMBO J. 2013 May 17. doi: 10.1038/emboj.2013.105. PMID:23685356 doi:10.1038/emboj.2013.105
  1. ↑ Chen S, Saiyin H, Zeng X, Xi J, Liu X, Li X, Yu L. Isolation and functional analysis of human HMBOX1, a homeobox containing protein with transcriptional repressor activity. Cytogenet Genome Res. 2006;114(2):131-6. PMID:16825764 doi:http://dx.doi.org/10.1159/000093328
  2. ↑ Zhang M, Chen S, Li Q, Ling Y, Zhang J, Yu L. Characterization of a novel human HMBOX1 splicing variant lacking the homeodomain and with attenuated transcription repressor activity. Mol Biol Rep. 2010 Jul;37(6):2767-72. doi: 10.1007/s11033-009-9815-9. Epub 2009, Sep 15. PMID:19757162 doi:http://dx.doi.org/10.1007/s11033-009-9815-9

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