4jnh

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m (Protected "4jnh" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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{{STRUCTURE_4jnh| PDB=4jnh | SCENE= }}
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===A unique spumavirus gag N-terminal domain with functional properties of orthoretroviral Matrix and Capsid===
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{{ABSTRACT_PUBMED_23675305}}
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The entry 4jnh is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/GAG_FOAMV GAG_FOAMV]] Involved in capsid formation and genome binding. Shortly after infection, interaction between incoming particle-associated Gag proteins and host dynein allows centrosomal targeting of the viral genome (associated to Gag), prior to nucleus translocation and integration into host genome.<ref>PMID:16160174</ref> <ref>PMID:12857789</ref>
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Authors: Taylor, I.A., Goldstone, D.C., Flower, T.G., Ball, N.J.
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==About this Structure==
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[[4jnh]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_spumaretrovirus Human spumaretrovirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JNH OCA].
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Description: A unique spumavirus gag N-terminal domain with functional properties of orthoretroviral Matrix and Capsid
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==Reference==
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<ref group="xtra">PMID:023675305</ref><references group="xtra"/><references/>
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[[Category: Human spumaretrovirus]]
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[[Category: Ball, N J.]]
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[[Category: Flower, T G.]]
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[[Category: Goldstone, D C.]]
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[[Category: Taylor, I A.]]
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[[Category: Coiled-coil]]
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[[Category: Env]]
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[[Category: Gag]]
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[[Category: Viral protein]]

Revision as of 15:42, 19 June 2013

Template:STRUCTURE 4jnh

Contents

A unique spumavirus gag N-terminal domain with functional properties of orthoretroviral Matrix and Capsid

Template:ABSTRACT PUBMED 23675305

Function

[GAG_FOAMV] Involved in capsid formation and genome binding. Shortly after infection, interaction between incoming particle-associated Gag proteins and host dynein allows centrosomal targeting of the viral genome (associated to Gag), prior to nucleus translocation and integration into host genome.[1] [2]

About this Structure

4jnh is a 2 chain structure with sequence from Human spumaretrovirus. Full crystallographic information is available from OCA.

Reference

  • Goldstone DC, Flower TG, Ball NJ, Sanz-Ramos M, Yap MW, Ogrodowicz RW, Stanke N, Reh J, Lindemann D, Stoye JP, Taylor IA. A Unique Spumavirus Gag N-terminal Domain with Functional Properties of Orthoretroviral Matrix and Capsid. PLoS Pathog. 2013 May;9(5):e1003376. doi: 10.1371/journal.ppat.1003376. Epub 2013, May 9. PMID:23675305 doi:10.1371/journal.ppat.1003376
  1. ↑ Cartellieri M, Herchenroder O, Rudolph W, Heinkelein M, Lindemann D, Zentgraf H, Rethwilm A. N-terminal Gag domain required for foamy virus particle assembly and export. J Virol. 2005 Oct;79(19):12464-76. PMID:16160174 doi:79/19/12464
  2. ↑ Petit C, Giron ML, Tobaly-Tapiero J, Bittoun P, Real E, Jacob Y, Tordo N, De The H, Saib A. Targeting of incoming retroviral Gag to the centrosome involves a direct interaction with the dynein light chain 8. J Cell Sci. 2003 Aug 15;116(Pt 16):3433-42. PMID:12857789 doi:http://dx.doi.org/10.1242/jcs.00613

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