4b03

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m (Protected "4b03" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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{{STRUCTURE_4b03| PDB=4b03 | SCENE= }}
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===6A Electron cryomicroscopy structure of immature Dengue virus serotype 1===
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{{ABSTRACT_PUBMED_23637416}}
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The entry 4b03 is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/G3F5K5_9FLAV G3F5K5_9FLAV]] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS026470_004_099774]
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Authors: Kostyuchenko, V.A., Zhang, Q., Tan, L.C., Ng, T.S., Lok, S.M.
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==About this Structure==
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[[4b03]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Dengue_virus_1 Dengue virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B03 OCA].
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Description: 6A Electron cryomicroscopy structure of immature Dengue virus serotype 1
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==Reference==
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<ref group="xtra">PMID:023637416</ref><references group="xtra"/><references/>
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[[Category: Dengue virus 1]]
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[[Category: Kostyuchenko, V A.]]
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[[Category: Lok, S M.]]
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[[Category: Ng, T S.]]
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[[Category: Tan, L C.]]
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[[Category: Zhang, Q.]]
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[[Category: Flavivirus]]
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[[Category: Prm protein]]
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[[Category: Virus]]

Revision as of 15:46, 19 June 2013

Template:STRUCTURE 4b03

Contents

6A Electron cryomicroscopy structure of immature Dengue virus serotype 1

Template:ABSTRACT PUBMED 23637416

Function

[G3F5K5_9FLAV] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS026470_004_099774]

About this Structure

4b03 is a 6 chain structure with sequence from Dengue virus 1. Full crystallographic information is available from OCA.

Reference

  • Kostyuchenko VA, Zhang Q, Tan JL, Ng TS, Lok SM. Immature and mature dengue serotype 1 virus structures provide insight into the maturation process. J Virol. 2013 Jul;87(13):7700-7. doi: 10.1128/JVI.00197-13. Epub 2013 May 1. PMID:23637416 doi:10.1128/JVI.00197-13

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OCA

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