2hde
From Proteopedia
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==Overview== | ==Overview== | ||
| - | Signal transduction pathways are frequently found to repress transcription | + | Signal transduction pathways are frequently found to repress transcription of target genes in the absence of stimulation and, conversely, to upregulate transcription in the presence of a signal. Transcription factors are central in this dual regulatory mechanism and widely use a generalized mechanism to repress transcription through recruitment of a Sin3-histone deacetylase (HDAC) complex to their binding sites on DNA. The protein SAP18 (Sin3-associated polypeptide of 18 kDa) has been shown to play a key role in gene-specific recruitment of the HDAC complex by a number of transcription factors including Gli, GAGA, and Bicoid. The solution structure of SAP18 reveals a ubiquitin-like fold with several large loop insertions relative to other family members. This fold supports the functional role of SAP18 as a protein-protein adapter module and provides insight for how SAP18 may bridge the Sin3-HDAC complex to transcription factors. |
==About this Structure== | ==About this Structure== | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Fairbrother, W | + | [[Category: Fairbrother, W J.]] |
| - | [[Category: McCallum, S | + | [[Category: McCallum, S A.]] |
[[Category: Pan, B.]] | [[Category: Pan, B.]] | ||
| - | [[Category: Yin, J | + | [[Category: Yin, J P.]] |
[[Category: bicoid]] | [[Category: bicoid]] | ||
[[Category: gaga]] | [[Category: gaga]] | ||
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[[Category: transcriptional repressor]] | [[Category: transcriptional repressor]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:40:42 2008'' |
Revision as of 15:40, 21 February 2008
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Solution Structure of Human SAP18
Overview
Signal transduction pathways are frequently found to repress transcription of target genes in the absence of stimulation and, conversely, to upregulate transcription in the presence of a signal. Transcription factors are central in this dual regulatory mechanism and widely use a generalized mechanism to repress transcription through recruitment of a Sin3-histone deacetylase (HDAC) complex to their binding sites on DNA. The protein SAP18 (Sin3-associated polypeptide of 18 kDa) has been shown to play a key role in gene-specific recruitment of the HDAC complex by a number of transcription factors including Gli, GAGA, and Bicoid. The solution structure of SAP18 reveals a ubiquitin-like fold with several large loop insertions relative to other family members. This fold supports the functional role of SAP18 as a protein-protein adapter module and provides insight for how SAP18 may bridge the Sin3-HDAC complex to transcription factors.
About this Structure
2HDE is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structure of SAP18: a ubiquitin fold in histone deacetylase complex assembly., McCallum SA, Bazan JF, Merchant M, Yin J, Pan B, de Sauvage FJ, Fairbrother WJ, Biochemistry. 2006 Oct 3;45(39):11974-82. PMID:17002296
Page seeded by OCA on Thu Feb 21 17:40:42 2008
Categories: Homo sapiens | Single protein | Fairbrother, W J. | McCallum, S A. | Pan, B. | Yin, J P. | Bicoid | Gaga | Gli | Hdac | Histone deacetylase | Sin3 | Transcriptional repressor
