3zgc

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m (Protected "3zgc" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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{{STRUCTURE_3zgc| PDB=3zgc | SCENE= }}
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===crystal structure of the KEAP1-NEH2 complex===
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{{ABSTRACT_PUBMED_23722832}}
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The entry 3zgc is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/NF2L2_HUMAN NF2L2_HUMAN]] Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region.<ref>PMID:11035812</ref>
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Authors: Hoerer, S., Reinert, D., Ostmann, K., Hoevels, Y., Nar, H.
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==About this Structure==
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[[3zgc]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZGC OCA].
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Description: crystal structure of the KEAP1-NEH2 complex
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==Reference==
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<ref group="xtra">PMID:023722832</ref><references group="xtra"/><references/>
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[[Category: Homo sapiens]]
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[[Category: Hoerer, S.]]
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[[Category: Hoevels, Y.]]
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[[Category: Nar, H.]]
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[[Category: Ostmann, K.]]
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[[Category: Reinert, D.]]
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[[Category: Protein-peptide complex]]
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[[Category: Transcription]]

Revision as of 15:55, 19 June 2013

Template:STRUCTURE 3zgc

Contents

crystal structure of the KEAP1-NEH2 complex

Template:ABSTRACT PUBMED 23722832

Function

[NF2L2_HUMAN] Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region.[1]

About this Structure

3zgc is a 3 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Horer S, Reinert D, Ostmann K, Hoevels Y, Nar H. Crystal-contact engineering to obtain a crystal form of the Kelch domain of human Keap1 suitable for ligand-soaking experiments. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Jun;69(Pt 6):592-6. doi:, 10.1107/S174430911301124X. Epub 2013 May 23. PMID:23722832 doi:10.1107/S174430911301124X
  1. ↑ Huang HC, Nguyen T, Pickett CB. Regulation of the antioxidant response element by protein kinase C-mediated phosphorylation of NF-E2-related factor 2. Proc Natl Acad Sci U S A. 2000 Nov 7;97(23):12475-80. PMID:11035812 doi:http://dx.doi.org/10.1073/pnas.220418997

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