4ixf

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'''Unreleased structure'''
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{{STRUCTURE_4ixf| PDB=4ixf | SCENE= }}
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===pcDHFR-269 F69N variant===
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{{ABSTRACT_PUBMED_23627352}}
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The entry 4ixf is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/DYR_PNECA DYR_PNECA]] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
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Authors: Cody, V.
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==About this Structure==
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[[4ixf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pneumocystis_carinii Pneumocystis carinii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IXF OCA].
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Description: pcDHFR-269 F69N variant
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==Reference==
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<ref group="xtra">PMID:023627352</ref><references group="xtra"/><references/>
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[[Category: Dihydrofolate reductase]]
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[[Category: Pneumocystis carinii]]
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[[Category: Cody, V.]]
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[[Category: Oxidoreductase-inhibitor complex]]
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[[Category: Pcdhfr-269-nadph f69n ternary complex]]
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[[Category: Reductase]]

Revision as of 15:57, 19 June 2013

Template:STRUCTURE 4ixf

Contents

pcDHFR-269 F69N variant

Template:ABSTRACT PUBMED 23627352

Function

[DYR_PNECA] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.

About this Structure

4ixf is a 1 chain structure with sequence from Pneumocystis carinii. Full crystallographic information is available from OCA.

Reference

  • Gangjee A, Namjoshi OA, Raghavan S, Queener SF, Kisliuk RL, Cody V. Design, synthesis and molecular modeling of novel pyrido[2,3-d]pyrimidine analogs as antifolates: Application of Buchwald-Hartwig aminations of heterocycles. J Med Chem. 2013 Apr 29. PMID:23627352 doi:10.1021/jm400086g

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OCA

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