2hek
From Proteopedia
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==Overview== | ==Overview== | ||
| - | Using single-wavelength anomalous dispersion data obtained from a | + | Using single-wavelength anomalous dispersion data obtained from a gold-derivatized crystal, the X-ray crystal structure of the protein 067745_AQUAE from the prokaryotic organism Aquifex aeolicus has been determined to a resolution of 2.0 A. Amino-acid residues 1-371 of the 44 kDa protein were identified by Pfam as an HD domain and a member of the metal-dependent phosphohydrolase superfamily (accession No. PF01966). Although three families from this large and diverse group of enzymatic proteins are represented in the PDB, the structure of 067745_AQUAE reveals a unique fold that is unlike the others and that is likely to represent a new subfamily, further organizing the families and characterizing the proteins. Data are presented that provide the first insights into the structural organization of the proteins within this clan and a distal alternative GDP-binding domain outside the metal-binding active site is proposed. |
==About this Structure== | ==About this Structure== | ||
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[[Category: Aquifex aeolicus]] | [[Category: Aquifex aeolicus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Adams, P | + | [[Category: Adams, P D.]] |
| - | [[Category: BSGC, Berkeley | + | [[Category: BSGC, Berkeley Structural Genomics Center.]] |
[[Category: Jancarik, J.]] | [[Category: Jancarik, J.]] | ||
[[Category: Kim, R.]] | [[Category: Kim, R.]] | ||
| - | [[Category: Kim, S | + | [[Category: Kim, S H.]] |
[[Category: Oganesyan, V.]] | [[Category: Oganesyan, V.]] | ||
[[Category: BR]] | [[Category: BR]] | ||
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[[Category: unknown function]] | [[Category: unknown function]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:41:00 2008'' |
Revision as of 15:41, 21 February 2008
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Crystal structure of O67745, a hypothetical protein from Aquifex aeolicus at 2.0 A resolution.
Overview
Using single-wavelength anomalous dispersion data obtained from a gold-derivatized crystal, the X-ray crystal structure of the protein 067745_AQUAE from the prokaryotic organism Aquifex aeolicus has been determined to a resolution of 2.0 A. Amino-acid residues 1-371 of the 44 kDa protein were identified by Pfam as an HD domain and a member of the metal-dependent phosphohydrolase superfamily (accession No. PF01966). Although three families from this large and diverse group of enzymatic proteins are represented in the PDB, the structure of 067745_AQUAE reveals a unique fold that is unlike the others and that is likely to represent a new subfamily, further organizing the families and characterizing the proteins. Data are presented that provide the first insights into the structural organization of the proteins within this clan and a distal alternative GDP-binding domain outside the metal-binding active site is proposed.
About this Structure
2HEK is a Single protein structure of sequence from Aquifex aeolicus with , , , , and as ligands. Known structural/functional Sites: , , , , , , , , , , , , , , , , , , , , and . Full crystallographic information is available from OCA.
Reference
Structure of O67745_AQUAE, a hypothetical protein from Aquifex aeolicus., Oganesyan V, Adams PD, Jancarik J, Kim R, Kim SH, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 May 1;63(Pt, 5):369-74. Epub 2007 Apr 28. PMID:17565173
Page seeded by OCA on Thu Feb 21 17:41:00 2008
Categories: Aquifex aeolicus | Single protein | Adams, P D. | BSGC, Berkeley Structural Genomics Center. | Jancarik, J. | Kim, R. | Kim, S H. | Oganesyan, V. | BR | CL | GDP | GOL | PO4 | ZN | Berkeley structural genomics center | Bsgc | Predominantly alpha helical protein with gdp binding site and active site being far from each other | Protein structure initiative | Psi | Structural genomics | Unknown function
