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4jgc

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'''Unreleased structure'''
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{{STRUCTURE_4jgc| PDB=4jgc | SCENE= }}
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===Human TDG N140A mutant IN A COMPLEX WITH 5-carboxylcytosine (5caC)===
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{{ABSTRACT_PUBMED_23680598}}
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The entry 4jgc is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/TDG_HUMAN TDG_HUMAN]] In the DNA of higher eukaryotes, hydrolytic deamination of 5-methylcytosine to thymine leads to the formation of G/T mismatches. This enzyme corrects G/T mispairs to G/C pairs. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and a mispaired thymine. In addition to the G/T, it can remove thymine also from C/T and T/T mispairs in the order G/T >> C/T > T/T. It has no detectable activity on apyrimidinic sites and does not catalyze the removal of thymine from A/T pairs or from single-stranded DNA. It can also remove uracil and 5-bromouracil from mispairs with guanine.
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Authors: Hashimoto, H., Zhang, X., Cheng, X.
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==About this Structure==
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[[4jgc]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JGC OCA].
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Description: Human TDG N140A mutant IN A COMPLEX WITH 5-carboxylcytosine (5caC)
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==Reference==
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<ref group="xtra">PMID:023680598</ref><references group="xtra"/><references/>
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[[Category: Homo sapiens]]
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[[Category: Thymine-DNA glycosylase]]
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[[Category: Cheng, X.]]
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[[Category: Hashimoto, H.]]
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[[Category: Zhang, X.]]
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[[Category: 5-carboxylcytosine]]
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[[Category: Dna 5mc oxidation]]
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[[Category: Dna demethylation]]
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[[Category: Dna modification]]
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[[Category: Epigenetic regulation]]
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[[Category: Hydrolase-dna complex]]
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[[Category: Thymine dna glycosylase]]

Revision as of 16:11, 19 June 2013

Template:STRUCTURE 4jgc

Contents

Human TDG N140A mutant IN A COMPLEX WITH 5-carboxylcytosine (5caC)

Template:ABSTRACT PUBMED 23680598

Function

[TDG_HUMAN] In the DNA of higher eukaryotes, hydrolytic deamination of 5-methylcytosine to thymine leads to the formation of G/T mismatches. This enzyme corrects G/T mispairs to G/C pairs. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and a mispaired thymine. In addition to the G/T, it can remove thymine also from C/T and T/T mispairs in the order G/T >> C/T > T/T. It has no detectable activity on apyrimidinic sites and does not catalyze the removal of thymine from A/T pairs or from single-stranded DNA. It can also remove uracil and 5-bromouracil from mispairs with guanine.

About this Structure

4jgc is a 3 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Hashimoto H, Zhang X, Cheng X. Activity and crystal structure of human thymine DNA glycosylase mutant N140A with 5-carboxylcytosine DNA at low pH. DNA Repair (Amst). 2013 May 13. pii: S1568-7864(13)00084-0. doi:, 10.1016/j.dnarep.2013.04.003. PMID:23680598 doi:10.1016/j.dnarep.2013.04.003

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OCA

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