3zc7

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m (Protected "3zc7" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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{{STRUCTURE_3zc7| PDB=3zc7 | SCENE= }}
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===VbhT Fic protein from Bartonella schoenbuchensis in complex with VbhA antitoxin and ATP===
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{{ABSTRACT_PUBMED_23738009}}
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The entry 3zc7 is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/VBHT_BARSR VBHT_BARSR]] Toxic component of a toxin-antitoxin (TA) module VbhT-VbhA. Adenylyltransferase involved in virulence by mediating the addition of adenosine 5'-monophosphate (AMP) to specific residue of host GTPases. The resulting AMPylation affects GTPases, impairing actin assembly in infected cells. [[http://www.uniprot.org/uniprot/VBHA_BARSR VBHA_BARSR]] Antitoxin component of a toxin-antitoxin (TA) module VbhT-VbhA. Acts by inhibiting the adenylyltransferase activity of VbhT; competes with ATP-binding and prevents productive ATP-binding to VbhT.
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Authors: Goepfert, A., Schirmer, T.
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==About this Structure==
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[[3zc7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bartonella_schoenbuchensis Bartonella schoenbuchensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZC7 OCA].
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Description: VbhT Fic protein from Bartonella schoenbuchensis in complex with VbhA antitoxin and ATP
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==Reference==
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<ref group="xtra">PMID:023738009</ref><references group="xtra"/><references/>
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[[Category: Bartonella schoenbuchensis]]
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[[Category: Goepfert, A.]]
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[[Category: Schirmer, T.]]
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[[Category: Adenylylation]]
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[[Category: Ampylation]]
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[[Category: Transferase-antitoxin complex]]

Revision as of 16:11, 19 June 2013

Template:STRUCTURE 3zc7

Contents

VbhT Fic protein from Bartonella schoenbuchensis in complex with VbhA antitoxin and ATP

Template:ABSTRACT PUBMED 23738009

Function

[VBHT_BARSR] Toxic component of a toxin-antitoxin (TA) module VbhT-VbhA. Adenylyltransferase involved in virulence by mediating the addition of adenosine 5'-monophosphate (AMP) to specific residue of host GTPases. The resulting AMPylation affects GTPases, impairing actin assembly in infected cells. [VBHA_BARSR] Antitoxin component of a toxin-antitoxin (TA) module VbhT-VbhA. Acts by inhibiting the adenylyltransferase activity of VbhT; competes with ATP-binding and prevents productive ATP-binding to VbhT.

About this Structure

3zc7 is a 2 chain structure with sequence from Bartonella schoenbuchensis. Full crystallographic information is available from OCA.

Reference

  • Goepfert A, Stanger FV, Dehio C, Schirmer T. Conserved inhibitory mechanism and competent ATP binding mode for adenylyltransferases with fic fold. PLoS One. 2013 May 30;8(5):e64901. doi: 10.1371/journal.pone.0064901. Print 2013. PMID:23738009 doi:10.1371/journal.pone.0064901

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