This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


4bgd

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
'''Unreleased structure'''
+
{{STRUCTURE_4bgd| PDB=4bgd | SCENE= }}
 +
===Crystal structure of Brr2 in complex with the Jab1/MPN domain of Prp8===
 +
{{ABSTRACT_PUBMED_23727230}}
-
The entry 4bgd is ON HOLD until Paper Publication
+
==Function==
 +
[[http://www.uniprot.org/uniprot/PRP8_YEAST PRP8_YEAST]] Required for pre-spliceosome formation, which is the first step of pre-mRNA splicing. This protein is associated with snRNP U5. Has a role in branch site-3' splice site selection. Associates with the branch site-3' splice 3'-exon region. Also has a role in cell cycle.<ref>PMID:2835658</ref> <ref>PMID:9150140</ref> <ref>PMID:12773561</ref> <ref>PMID:18779563</ref>
-
Authors: Nguyen, T.H.D., Li, J., Nagai, K.
+
==About this Structure==
 +
[[4bgd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BGD OCA].
-
Description: Crystal structure of a splicing complex
+
==Reference==
 +
<ref group="xtra">PMID:023727230</ref><references group="xtra"/><references/>
 +
[[Category: RNA helicase]]
 +
[[Category: Saccharomyces cerevisiae]]
 +
[[Category: Li, J.]]
 +
[[Category: Nagai, K.]]
 +
[[Category: Nguyen, T H.D.]]
 +
[[Category: Retinitis pigmentosa]]
 +
[[Category: Rna helicase]]
 +
[[Category: Spliceosome]]
 +
[[Category: Transcription]]
 +
[[Category: U5 snrnp]]

Revision as of 16:17, 19 June 2013

Template:STRUCTURE 4bgd

Contents

Crystal structure of Brr2 in complex with the Jab1/MPN domain of Prp8

Template:ABSTRACT PUBMED 23727230

Function

[PRP8_YEAST] Required for pre-spliceosome formation, which is the first step of pre-mRNA splicing. This protein is associated with snRNP U5. Has a role in branch site-3' splice site selection. Associates with the branch site-3' splice 3'-exon region. Also has a role in cell cycle.[1] [2] [3] [4]

About this Structure

4bgd is a 2 chain structure with sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

  • Nguyen TH, Li J, Galej WP, Oshikane H, Newman AJ, Nagai K. Structural Basis of Brr2-Prp8 Interactions and Implications for U5 snRNP Biogenesis and the Spliceosome Active Site. Structure. 2013 May 29. pii: S0969-2126(13)00129-9. doi:, 10.1016/j.str.2013.04.017. PMID:23727230 doi:10.1016/j.str.2013.04.017
  1. ↑ Jackson SP, Lossky M, Beggs JD. Cloning of the RNA8 gene of Saccharomyces cerevisiae, detection of the RNA8 protein, and demonstration that it is essential for nuclear pre-mRNA splicing. Mol Cell Biol. 1988 Mar;8(3):1067-75. PMID:2835658
  2. ↑ Abovich N, Rosbash M. Cross-intron bridging interactions in the yeast commitment complex are conserved in mammals. Cell. 1997 May 2;89(3):403-12. PMID:9150140
  3. ↑ McPheeters DS, Muhlenkamp P. Spatial organization of protein-RNA interactions in the branch site-3' splice site region during pre-mRNA splicing in yeast. Mol Cell Biol. 2003 Jun;23(12):4174-86. PMID:12773561
  4. ↑ Yang K, Zhang L, Xu T, Heroux A, Zhao R. Crystal structure of the beta-finger domain of Prp8 reveals analogy to ribosomal proteins. Proc Natl Acad Sci U S A. 2008 Sep 16;105(37):13817-22. Epub 2008 Sep 8. PMID:18779563

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4bgd"
Personal tools