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4gul

From Proteopedia

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'''Unreleased structure'''
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{{STRUCTURE_4gul| PDB=4gul | SCENE= }}
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===Study on structure and function relationships in human ferric Pirin===
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The entry 4gul is ON HOLD until May 29 2014
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==Function==
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[[http://www.uniprot.org/uniprot/PIR_HUMAN PIR_HUMAN]] Possible transcriptional coregulator. May contribute to the regulation of cellular processes via its interaction with BCL3. May be required for efficient terminal myeloid maturation of hematopoietic cells. May play a role in the regulation of cell migration. May promote apoptosis when overexpressed. Has quercetin 2,3-dioxygenase activity (in vitro).<ref>PMID:9079676</ref> <ref>PMID:17288615</ref> <ref>PMID:20010624</ref> <ref>PMID:20711196</ref>
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Authors: Liu, F., Rehmani, I., Fu, R., Esaka, S., Chen, L., Serrano, V., Liu, A.
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==About this Structure==
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[[4gul]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GUL OCA].
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Description: Study on structure and function relationships in human ferric Pirin
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Homo sapiens]]
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[[Category: Quercetin 2,3-dioxygenase]]
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[[Category: Chen, L.]]
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[[Category: Esaka, S.]]
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[[Category: Fu, R.]]
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[[Category: Liu, A.]]
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[[Category: Liu, F.]]
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[[Category: Rehmani, I.]]
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[[Category: Serrano, V.]]
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[[Category: Beta sandwich]]
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[[Category: Cupin]]
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[[Category: Iron]]
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[[Category: Metal binding protein]]
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[[Category: Protein binding]]
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[[Category: Signaling protein]]
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[[Category: Transcription cofactor activity]]

Revision as of 16:20, 19 June 2013

Template:STRUCTURE 4gul

Contents

Study on structure and function relationships in human ferric Pirin

Function

[PIR_HUMAN] Possible transcriptional coregulator. May contribute to the regulation of cellular processes via its interaction with BCL3. May be required for efficient terminal myeloid maturation of hematopoietic cells. May play a role in the regulation of cell migration. May promote apoptosis when overexpressed. Has quercetin 2,3-dioxygenase activity (in vitro).[1] [2] [3] [4]

About this Structure

4gul is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  1. ↑ Wendler WM, Kremmer E, Forster R, Winnacker EL. Identification of pirin, a novel highly conserved nuclear protein. J Biol Chem. 1997 Mar 28;272(13):8482-9. PMID:9079676
  2. ↑ Gelbman BD, Heguy A, O'Connor TP, Zabner J, Crystal RG. Upregulation of pirin expression by chronic cigarette smoking is associated with bronchial epithelial cell apoptosis. Respir Res. 2007 Feb 8;8:10. PMID:17288615 doi:http://dx.doi.org/10.1186/1465-9921-8-10
  3. ↑ Licciulli S, Cambiaghi V, Scafetta G, Gruszka AM, Alcalay M. Pirin downregulation is a feature of AML and leads to impairment of terminal myeloid differentiation. Leukemia. 2010 Feb;24(2):429-37. doi: 10.1038/leu.2009.247. Epub 2009 Dec 10. PMID:20010624 doi:http://dx.doi.org/10.1038/leu.2009.247
  4. ↑ Miyazaki I, Simizu S, Okumura H, Takagi S, Osada H. A small-molecule inhibitor shows that pirin regulates migration of melanoma cells. Nat Chem Biol. 2010 Sep;6(9):667-73. Epub 2010 Aug 15. PMID:20711196 doi:10.1038/nchembio.423

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