4joi

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
'''Unreleased structure'''
+
{{STRUCTURE_4joi| PDB=4joi | SCENE= }}
 +
===Crystal structure of the human telomeric Stn1-Ten1 complex===
-
The entry 4joi is ON HOLD until Paper Publication
+
==Function==
 +
[[http://www.uniprot.org/uniprot/STN1_HUMAN STN1_HUMAN]] Component of the CST complex, a complex that binds to single-stranded DNA and is required to protect telomeres from DNA degradation. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. In addition to telomere protection, the CST complex has probably a more general role in DNA metabolism at non-telomeric sites.<ref>PMID:19854130</ref> <ref>PMID:19648609</ref> [[http://www.uniprot.org/uniprot/TEN1L_HUMAN TEN1L_HUMAN]] Component of the CST complex, a complex that binds to single-stranded DNA and is required to protect telomeres from DNA degradation. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. In addition to telomere protection, the CST complex has probably a more general role in DNA metabolism at non-telomeric sites.
-
Authors: Bryan, C., Rice, C., Harkisheimer, M., Schultz, D., Skordalakes, E.
+
==About this Structure==
 +
[[4joi]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JOI OCA].
-
Description: Crystal structure of the human telomeric Stn1-Ten1 complex
+
==Reference==
 +
<references group="xtra"/><references/>
 +
[[Category: Homo sapiens]]
 +
[[Category: Bryan, C.]]
 +
[[Category: Harkisheimer, M.]]
 +
[[Category: Rice, C.]]
 +
[[Category: Schultz, D.]]
 +
[[Category: Skordalakes, E.]]
 +
[[Category: Dna binding protein]]
 +
[[Category: Ob fold]]

Revision as of 16:21, 19 June 2013

Template:STRUCTURE 4joi

Contents

Crystal structure of the human telomeric Stn1-Ten1 complex

Function

[STN1_HUMAN] Component of the CST complex, a complex that binds to single-stranded DNA and is required to protect telomeres from DNA degradation. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. In addition to telomere protection, the CST complex has probably a more general role in DNA metabolism at non-telomeric sites.[1] [2] [TEN1L_HUMAN] Component of the CST complex, a complex that binds to single-stranded DNA and is required to protect telomeres from DNA degradation. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. In addition to telomere protection, the CST complex has probably a more general role in DNA metabolism at non-telomeric sites.

About this Structure

4joi is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  1. ↑ Miyake Y, Nakamura M, Nabetani A, Shimamura S, Tamura M, Yonehara S, Saito M, Ishikawa F. RPA-like mammalian Ctc1-Stn1-Ten1 complex binds to single-stranded DNA and protects telomeres independently of the Pot1 pathway. Mol Cell. 2009 Oct 23;36(2):193-206. PMID:19854130 doi:S1097-2765(09)00587-5
  2. ↑ Wan M, Qin J, Songyang Z, Liu D. OB fold-containing protein 1 (OBFC1), a human homolog of yeast Stn1, associates with TPP1 and is implicated in telomere length regulation. J Biol Chem. 2009 Sep 25;284(39):26725-31. Epub 2009 Aug 1. PMID:19648609 doi:M109.021105

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4joi"
Personal tools