3pka
From Proteopedia
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{{STRUCTURE_3pka| PDB=3pka | SCENE= }} | {{STRUCTURE_3pka| PDB=3pka | SCENE= }} | ||
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===M. tuberculosis MetAP with bengamide analog Y02, in Mn form=== | ===M. tuberculosis MetAP with bengamide analog Y02, in Mn form=== | ||
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{{ABSTRACT_PUBMED_21465667}} | {{ABSTRACT_PUBMED_21465667}} | ||
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| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/AMPM2_MYCTU AMPM2_MYCTU]] Removes the N-terminal methionine from nascent proteins, when the penultimate amino acid is alanine or proline, but enzyme activity is remarkably low when the second residue is phenylalanine or leucine. With glycine at the second position, Map is more active with a tetrapeptide than with a tripeptide.<ref>PMID:19688379</ref> <ref>PMID:20038112</ref> | ||
==About this Structure== | ==About this Structure== | ||
[[3pka]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PKA OCA]. | [[3pka]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PKA OCA]. | ||
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| - | ==See Also== | ||
| - | *[[Aminopeptidase|Aminopeptidase]] | ||
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID:021465667</ref><references group="xtra"/> | + | <ref group="xtra">PMID:021465667</ref><references group="xtra"/><references/> |
[[Category: Methionyl aminopeptidase]] | [[Category: Methionyl aminopeptidase]] | ||
[[Category: Mycobacterium tuberculosis]] | [[Category: Mycobacterium tuberculosis]] | ||
Revision as of 16:26, 19 June 2013
Contents |
M. tuberculosis MetAP with bengamide analog Y02, in Mn form
Template:ABSTRACT PUBMED 21465667
Function
[AMPM2_MYCTU] Removes the N-terminal methionine from nascent proteins, when the penultimate amino acid is alanine or proline, but enzyme activity is remarkably low when the second residue is phenylalanine or leucine. With glycine at the second position, Map is more active with a tetrapeptide than with a tripeptide.[1] [2]
About this Structure
3pka is a 1 chain structure with sequence from Mycobacterium tuberculosis. Full crystallographic information is available from OCA.
Reference
- Lu JP, Yuan XH, Yuan H, Wang WL, Wan B, Franzblau SG, Ye QZ. Inhibition of Mycobacterium tuberculosis Methionine Aminopeptidases by Bengamide Derivatives. ChemMedChem. 2011 Apr 4. doi: 10.1002/cmdc.201100003. PMID:21465667 doi:10.1002/cmdc.201100003
- ↑ Zhang X, Chen S, Hu Z, Zhang L, Wang H. Expression and characterization of two functional methionine aminopeptidases from Mycobacterium tuberculosis H37Rv. Curr Microbiol. 2009 Nov;59(5):520-5. doi: 10.1007/s00284-009-9470-3. Epub 2009, Aug 18. PMID:19688379 doi:10.1007/s00284-009-9470-3
- ↑ Lu JP, Chai SC, Ye QZ. Catalysis and Inhibition of Mycobacterium tuberculosis Methionine Aminopeptidase. J Med Chem. 2009 Dec 28. PMID:20038112 doi:10.1021/jm901624n
