4hf1

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{{STRUCTURE_4hf1| PDB=4hf1 | SCENE= }}
{{STRUCTURE_4hf1| PDB=4hf1 | SCENE= }}
===Crystal Structure of IscR bound to its promoter===
===Crystal Structure of IscR bound to its promoter===
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{{ABSTRACT_PUBMED_23644595}}
==Function==
==Function==
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==Reference==
==Reference==
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<references group="xtra"/><references/>
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<ref group="xtra">PMID:023644595</ref><references group="xtra"/><references/>
[[Category: Escherichia coli k-12]]
[[Category: Escherichia coli k-12]]
[[Category: Phillips, K J.]]
[[Category: Phillips, K J.]]

Revision as of 16:32, 19 June 2013

Template:STRUCTURE 4hf1

Contents

Crystal Structure of IscR bound to its promoter

Template:ABSTRACT PUBMED 23644595

Function

[ISCR_ECOLI] Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins. Transcriptional repressor of the iscRSUA operon, which is involved in the assembly of Fe-S clusters into Fe-S proteins. In its apoform, under conditions of oxidative stress or iron deprivation, it activates the suf operon, which is a second operon involved in the assembly of Fe-S clusters. Represses its own transcription as well as that of toxin rnlA.[1] [2] [3]

About this Structure

4hf1 is a 4 chain structure with sequence from Escherichia coli k-12. Full crystallographic information is available from OCA.

Reference

  • Rajagopalan S, Teter SJ, Zwart PH, Brennan RG, Phillips KJ, Kiley PJ. Studies of IscR reveal a unique mechanism for metal-dependent regulation of DNA binding specificity. Nat Struct Mol Biol. 2013 Jun;20(6):740-7. doi: 10.1038/nsmb.2568. Epub 2013 May , 5. PMID:23644595 doi:10.1038/nsmb.2568
  1. ↑ Schwartz CJ, Giel JL, Patschkowski T, Luther C, Ruzicka FJ, Beinert H, Kiley PJ. IscR, an Fe-S cluster-containing transcription factor, represses expression of Escherichia coli genes encoding Fe-S cluster assembly proteins. Proc Natl Acad Sci U S A. 2001 Dec 18;98(26):14895-900. Epub 2001 Dec 11. PMID:11742080 doi:10.1073/pnas.251550898
  2. ↑ Yeo WS, Lee JH, Lee KC, Roe JH. IscR acts as an activator in response to oxidative stress for the suf operon encoding Fe-S assembly proteins. Mol Microbiol. 2006 Jul;61(1):206-18. PMID:16824106 doi:10.1111/j.1365-2958.2006.05220.x
  3. ↑ Otsuka Y, Miki K, Koga M, Katayama N, Morimoto W, Takahashi Y, Yonesaki T. IscR regulates RNase LS activity by repressing rnlA transcription. Genetics. 2010 Jul;185(3):823-30. doi: 10.1534/genetics.110.114462. Epub 2010 Apr, 26. PMID:20421606 doi:10.1534/genetics.110.114462

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OCA

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