3l1p
From Proteopedia
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{{STRUCTURE_3l1p| PDB=3l1p | SCENE= }} | {{STRUCTURE_3l1p| PDB=3l1p | SCENE= }} | ||
===POU protein:DNA complex=== | ===POU protein:DNA complex=== | ||
| + | {{ABSTRACT_PUBMED_23376973}} | ||
==Function== | ==Function== | ||
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==Reference== | ==Reference== | ||
| - | <references group="xtra"/><references/> | + | <ref group="xtra">PMID:023376973</ref><references group="xtra"/><references/> |
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Groves, M R.]] | [[Category: Groves, M R.]] | ||
Revision as of 17:55, 19 June 2013
Contents |
POU protein:DNA complex
Template:ABSTRACT PUBMED 23376973
Function
[PO5F1_MOUSE] Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Forms a trimeric complex with SOX2 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency.[1] [2]
About this Structure
3l1p is a 4 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
- Esch D, Vahokoski J, Groves MR, Pogenberg V, Cojocaru V, Vom Bruch H, Han D, Drexler HC, Arauzo-Bravo MJ, Ng CK, Jauch R, Wilmanns M, Scholer HR. A unique Oct4 interface is crucial for reprogramming to pluripotency. Nat Cell Biol. 2013 Mar;15(3):295-301. doi: 10.1038/ncb2680. Epub 2013 Feb 3. PMID:23376973 doi:10.1038/ncb2680
- ↑ Zhang Z, Liao B, Xu M, Jin Y. Post-translational modification of POU domain transcription factor Oct-4 by SUMO-1. FASEB J. 2007 Oct;21(12):3042-51. Epub 2007 May 11. PMID:17496161 doi:fj.06-6914com
- ↑ Wei F, Scholer HR, Atchison ML. Sumoylation of Oct4 enhances its stability, DNA binding, and transactivation. J Biol Chem. 2007 Jul 20;282(29):21551-60. Epub 2007 May 24. PMID:17525163 doi:M611041200
