4ghs

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'''Unreleased structure'''
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{{STRUCTURE_4ghs| PDB=4ghs | SCENE= }}
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===Crystal structure of human GLTP bound with 12:0 disulfatide (orthorombic form; two subunits in asymmetric unit)===
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{{ABSTRACT_PUBMED_23519669}}
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The entry 4ghs is ON HOLD until sometime in the future
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==Function==
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[[http://www.uniprot.org/uniprot/GLTP_HUMAN GLTP_HUMAN]] Accelerates the intermembrane transfer of various glycolipids. Catalyzes the transfer of various glycosphingolipids between membranes but does not catalyze the transfer of phospholipids. May be involved in the intracellular translocation of glucosylceramides.<ref>PMID:18261224</ref> <ref>PMID:15504043</ref> <ref>PMID:17980653</ref> <ref>PMID:15329726</ref>
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Authors: Samygina, V.R., Popov, A.N., Goni-de-Cerio, F., Cabo-Bilbao, A., Malinina, L.
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==About this Structure==
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[[4ghs]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GHS OCA].
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Description: Crystal structure of human GLTP bound with 12:0 disulfatide (orthorombic form; two subunits in asymmetric unit)
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==Reference==
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<ref group="xtra">PMID:023519669</ref><references group="xtra"/><references/>
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[[Category: Homo sapiens]]
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[[Category: Cabo-Bilbao, A.]]
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[[Category: Goni-de-Cerio, F.]]
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[[Category: Malinina, L.]]
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[[Category: Popov, A N.]]
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[[Category: Samygina, V R.]]
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[[Category: Gltp-fold]]
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[[Category: Lipid transport]]

Revision as of 17:56, 19 June 2013

Template:STRUCTURE 4ghs

Contents

Crystal structure of human GLTP bound with 12:0 disulfatide (orthorombic form; two subunits in asymmetric unit)

Template:ABSTRACT PUBMED 23519669

Function

[GLTP_HUMAN] Accelerates the intermembrane transfer of various glycolipids. Catalyzes the transfer of various glycosphingolipids between membranes but does not catalyze the transfer of phospholipids. May be involved in the intracellular translocation of glucosylceramides.[1] [2] [3] [4]

About this Structure

4ghs is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Samygina VR, Ochoa-Lizarralde B, Popov AN, Cabo-Bilbao A, Goni-de-Cerio F, Molotkovsky JG, Patel DJ, Brown RE, Malinina L. Structural insights into lipid-dependent reversible dimerization of human GLTP. Acta Crystallogr D Biol Crystallogr. 2013 Apr;69(Pt 4):603-16. doi:, 10.1107/S0907444913000024. Epub 2013 Mar 14. PMID:23519669 doi:10.1107/S0907444913000024
  1. ↑ Zou X, Chung T, Lin X, Malakhova ML, Pike HM, Brown RE. Human glycolipid transfer protein (GLTP) genes: organization, transcriptional status and evolution. BMC Genomics. 2008 Feb 8;9:72. PMID:18261224 doi:1471-2164-9-72
  2. ↑ Rao CS, Lin X, Pike HM, Molotkovsky JG, Brown RE. Glycolipid transfer protein mediated transfer of glycosphingolipids between membranes: a model for action based on kinetic and thermodynamic analyses. Biochemistry. 2004 Nov 2;43(43):13805-15. PMID:15504043 doi:10.1021/bi0492197
  3. ↑ Tuuf J, Mattjus P. Human glycolipid transfer protein--intracellular localization and effects on the sphingolipid synthesis. Biochim Biophys Acta. 2007 Nov;1771(11):1353-63. Epub 2007 Sep 21. PMID:17980653 doi:S1388-1981(07)00196-5
  4. ↑ Malinina L, Malakhova ML, Teplov A, Brown RE, Patel DJ. Structural basis for glycosphingolipid transfer specificity. Nature. 2004 Aug 26;430(7003):1048-53. PMID:15329726 doi:10.1038/nature02856

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