3hps
From Proteopedia
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| - | [[Image:3hps.png|left|200px]] | ||
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{{STRUCTURE_3hps| PDB=3hps | SCENE= }} | {{STRUCTURE_3hps| PDB=3hps | SCENE= }} | ||
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===Crystal structure of Mycobacterium tuberculosis LeuA complexed with ketoisocaproate (KIC)=== | ===Crystal structure of Mycobacterium tuberculosis LeuA complexed with ketoisocaproate (KIC)=== | ||
| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/LEU1_MYCTU LEU1_MYCTU]] Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity). | ||
==About this Structure== | ==About this Structure== | ||
| - | [[3hps]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | [[3hps]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_h37rv Mycobacterium tuberculosis h37rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HPS OCA]. |
[[Category: 2-isopropylmalate synthase]] | [[Category: 2-isopropylmalate synthase]] | ||
| - | [[Category: Mycobacterium tuberculosis]] | + | [[Category: Mycobacterium tuberculosis h37rv]] |
[[Category: Baker, E N.]] | [[Category: Baker, E N.]] | ||
[[Category: Koon, N.]] | [[Category: Koon, N.]] | ||
Revision as of 18:19, 19 June 2013
Crystal structure of Mycobacterium tuberculosis LeuA complexed with ketoisocaproate (KIC)
Function
[LEU1_MYCTU] Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity).
About this Structure
3hps is a 2 chain structure with sequence from Mycobacterium tuberculosis h37rv. Full crystallographic information is available from OCA.
Categories: 2-isopropylmalate synthase | Mycobacterium tuberculosis h37rv | Baker, E N. | Koon, N. | Squire, C J. | Amino-acid biosynthesis | Branched-chain amino acid biosynthesis | Enzyme | Leua | Leucine biosynthesis | Mycobacterium tuberculosis | Regulatory domain | Substrate | Tim barrel | Transferase
