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4bhc
From Proteopedia
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==About this Structure== | ==About this Structure== | ||
[[4bhc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_h37rv Mycobacterium tuberculosis h37rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BHC OCA]. | [[4bhc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_h37rv Mycobacterium tuberculosis h37rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BHC OCA]. | ||
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| + | ==Reference== | ||
| + | <ref group="xtra">PMID:023564173</ref><references group="xtra"/><references/> | ||
[[Category: Mycobacterium tuberculosis h37rv]] | [[Category: Mycobacterium tuberculosis h37rv]] | ||
[[Category: Casazza, V.]] | [[Category: Casazza, V.]] | ||
Revision as of 21:09, 19 June 2013
Contents |
CRYSTAL STRUCTURE OF THE M. TUBERCULOSIS O6-METHYLGUANINE METHYLTRANSFERASE R37L VARIANT
Template:ABSTRACT PUBMED 23564173
Function
[OGT_MYCTU] Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated (By similarity).
About this Structure
4bhc is a 1 chain structure with sequence from Mycobacterium tuberculosis h37rv. Full crystallographic information is available from OCA.
Reference
- Miggiano R, Casazza V, Garavaglia S, Ciaramella M, Perugino G, Rizzi M, Rossi F. BIOCHEMICAL AND STRUCTURAL STUDIES ON THE M. TUBERCULOSIS O6-METHYLGUANINE METHYLTRANSFERASE AND MUTATED VARIANTS. J Bacteriol. 2013 Apr 5. PMID:23564173 doi:10.1128/JB.02298-12
