4e91

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[[Image:4e91.png|left|200px]]
 
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{{STRUCTURE_4e91| PDB=4e91 | SCENE= }}
{{STRUCTURE_4e91| PDB=4e91 | SCENE= }}
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===Crystal Structure of the N-Terminal Domain of HIV-1 Capsid in Complex With Inhibitor BD3===
===Crystal Structure of the N-Terminal Domain of HIV-1 Capsid in Complex With Inhibitor BD3===
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{{ABSTRACT_PUBMED_22496222}}
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==Function==
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[[http://www.uniprot.org/uniprot/Q79791_9HIV1 Q79791_9HIV1]] Capsid protein p24 forms the conical core of the virus that encapsulates the genomic RNA-nucleocapsid complex (By similarity).[SAAS:SAAS000071_004_008806] Nucleocapsid protein p7 encapsulates and protects viral dimeric unspliced (genomic) RNA. Binds these RNAs through its zinc fingers (By similarity).[SAAS:SAAS000071_004_011858]
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(as it appears on PubMed at http://www.pubmed.gov), where 22496222 is the PubMed ID number.
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{{ABSTRACT_PUBMED_22496222}}
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==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:022496222</ref><references group="xtra"/>
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<ref group="xtra">PMID:022496222</ref><references group="xtra"/><references/>
[[Category: Human immunodeficiency virus 1]]
[[Category: Human immunodeficiency virus 1]]
[[Category: Lemke, C T.]]
[[Category: Lemke, C T.]]

Revision as of 21:09, 19 June 2013

Template:STRUCTURE 4e91

Contents

Crystal Structure of the N-Terminal Domain of HIV-1 Capsid in Complex With Inhibitor BD3

Template:ABSTRACT PUBMED 22496222

Function

[Q79791_9HIV1] Capsid protein p24 forms the conical core of the virus that encapsulates the genomic RNA-nucleocapsid complex (By similarity).[SAAS:SAAS000071_004_008806] Nucleocapsid protein p7 encapsulates and protects viral dimeric unspliced (genomic) RNA. Binds these RNAs through its zinc fingers (By similarity).[SAAS:SAAS000071_004_011858]

About this Structure

4e91 is a 2 chain structure with sequence from Human immunodeficiency virus 1. Full crystallographic information is available from OCA.

Reference

  • Lemke CT, Titolo S, von Schwedler U, Goudreau N, Mercier JF, Wardrop E, Faucher AM, Coulombe R, Banik SS, Fader L, Gagnon A, Kawai SH, Rancourt J, Tremblay M, Yoakim C, Simoneau B, Archambault J, Sundquist WI, Mason SW. Distinct effects of two HIV-1 capsid assembly inhibitor families that bind the same site within the N-terminal domain of the viral CA protein. J Virol. 2012 Apr 11. PMID:22496222 doi:10.1128/JVI.00493-12

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OCA

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