2m7f
From Proteopedia
(Difference between revisions)
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| - | + | {{STRUCTURE_2m7f| PDB=2m7f | SCENE= }} | |
| + | ===The C-terminal Region of Disintegrin Modulate its 3D Conformation and Cooperate with RGD Loop in Regulating Integrins Recognitions=== | ||
| - | + | ==Function== | |
| + | [[http://www.uniprot.org/uniprot/VM2RH_CALRH VM2RH_CALRH]] Metalloproteinase rhodostoxin: snake venom metalloproteinase that impairs hemostasis in the envenomed animal (By similarity). Disintegrin rhodostomin: inhibit platelet aggregation induced by ADP, thrombin, platelet-activating factor and collagen. Acts by inhibiting fibrinogen interaction with platelet receptors GPIIb/GPIIIa (ITGA2B/ITGB3). | ||
| - | + | ==About this Structure== | |
| - | + | [[2m7f]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Calloselasma_rhodostoma Calloselasma rhodostoma]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M7F OCA]. | |
| - | + | [[Category: Calloselasma rhodostoma]] | |
| + | [[Category: Chang, Y.]] | ||
| + | [[Category: Chuang, W.]] | ||
| + | [[Category: C-terminal region mutation]] | ||
| + | [[Category: Hydrolase]] | ||
| + | [[Category: Rgd motif]] | ||
| + | [[Category: Rhodostomin mutant protein]] | ||
Revision as of 06:22, 20 June 2013
The C-terminal Region of Disintegrin Modulate its 3D Conformation and Cooperate with RGD Loop in Regulating Integrins Recognitions
Function
[VM2RH_CALRH] Metalloproteinase rhodostoxin: snake venom metalloproteinase that impairs hemostasis in the envenomed animal (By similarity). Disintegrin rhodostomin: inhibit platelet aggregation induced by ADP, thrombin, platelet-activating factor and collagen. Acts by inhibiting fibrinogen interaction with platelet receptors GPIIb/GPIIIa (ITGA2B/ITGB3).
About this Structure
2m7f is a 1 chain structure with sequence from Calloselasma rhodostoma. Full experimental information is available from OCA.
