This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


4fxr

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
'''Unreleased structure'''
+
{{STRUCTURE_4fxr| PDB=4fxr | SCENE= }}
 +
===Crystal structure of the mutant T159V.R203A of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with inhibitor BMP===
 +
{{ABSTRACT_PUBMED_23030629}}
-
The entry 4fxr is ON HOLD until Paper Publication
+
==Function==
 +
[[http://www.uniprot.org/uniprot/PYRF_METTH PYRF_METTH]] Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).[HAMAP-Rule:MF_01200_A]
-
Authors: Fedorov, A.A., Fedorov, E.V., Desai, B., Gerlt, J.A., Almo, S.C.
+
==About this Structure==
 +
[[4fxr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Methanothermobacter_thermautotrophicus_str._delta_h Methanothermobacter thermautotrophicus str. delta h]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FXR OCA].
-
Description: Crystal structure of the mutant T159V.R203A of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with inhibitor BMP
+
==Reference==
 +
<ref group="xtra">PMID:023030629</ref><references group="xtra"/><references/>
 +
[[Category: Methanothermobacter thermautotrophicus str. delta h]]
 +
[[Category: Orotidine-5'-phosphate decarboxylase]]
 +
[[Category: Almo, S C.]]
 +
[[Category: Desai, B.]]
 +
[[Category: Fedorov, A A.]]
 +
[[Category: Fedorov, E V.]]
 +
[[Category: Gerlt, J A.]]
 +
[[Category: Inhibitor bmp]]
 +
[[Category: Lyase-lyase inhibitor complex]]
 +
[[Category: Tim barrel]]

Revision as of 06:25, 20 June 2013

Template:STRUCTURE 4fxr

Contents

Crystal structure of the mutant T159V.R203A of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with inhibitor BMP

Template:ABSTRACT PUBMED 23030629

Function

[PYRF_METTH] Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).[HAMAP-Rule:MF_01200_A]

About this Structure

4fxr is a 2 chain structure with sequence from Methanothermobacter thermautotrophicus str. delta h. Full crystallographic information is available from OCA.

Reference

  • Desai BJ, Wood BM, Fedorov AA, Fedorov EV, Goryanova B, Amyes TL, Richard JP, Almo SC, Gerlt JA. Conformational Changes in Orotidine 5'-Monophosphate Decarboxylase: A Structure-Based Explanation for How the 5'-Phosphate Group Activates the Enzyme. Biochemistry. 2012 Oct 17. PMID:23030629 doi:10.1021/bi301188k

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4fxr"
Personal tools