2hnx
From Proteopedia
(New page: 200px<br /> <applet load="2hnx" size="450" color="white" frame="true" align="right" spinBox="true" caption="2hnx, resolution 1.50Å" /> '''Crystal Structure o...) |
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| - | [[Image:2hnx.gif|left|200px]]<br /> | + | [[Image:2hnx.gif|left|200px]]<br /><applet load="2hnx" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="2hnx" size=" | + | |
caption="2hnx, resolution 1.50Å" /> | caption="2hnx, resolution 1.50Å" /> | ||
'''Crystal Structure of aP2'''<br /> | '''Crystal Structure of aP2'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Human adipocyte lipid-binding protein (aP2) belongs to a family of | + | Human adipocyte lipid-binding protein (aP2) belongs to a family of intracellular lipid-binding proteins involved in the transport and storage of lipids. Here, the crystal structure of human aP2 with a bound palmitate is described at 1.5 A resolution. Unlike the known crystal structure of murine aP2 in complex with palmitate, this structure shows that the fatty acid is in a folded conformation and that the loop containing Phe57 acts as a lid to regulate ligand binding by excluding solvent exposure to the central binding cavity. |
==About this Structure== | ==About this Structure== | ||
| - | 2HNX is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with PO4, PLM and ACY as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http:// | + | 2HNX is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=PO4:'>PO4</scene>, <scene name='pdbligand=PLM:'>PLM</scene> and <scene name='pdbligand=ACY:'>ACY</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HNX OCA]. |
==Reference== | ==Reference== | ||
| - | Expression, purification, crystallization and structure of human adipocyte lipid-binding protein (aP2)., Marr E, Tardie M, Carty M, Brown Phillips T, Wang IK, Soeller W, Qiu X, Karam G, Acta | + | Expression, purification, crystallization and structure of human adipocyte lipid-binding protein (aP2)., Marr E, Tardie M, Carty M, Brown Phillips T, Wang IK, Soeller W, Qiu X, Karam G, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Nov 1;62(Pt, 11):1058-60. Epub 2006 Oct 25. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17077479 17077479] |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: Karam, G.]] | [[Category: Karam, G.]] | ||
[[Category: Marr, E.]] | [[Category: Marr, E.]] | ||
| - | [[Category: Phillips, T | + | [[Category: Phillips, T Brown.]] |
[[Category: Qiu, X.]] | [[Category: Qiu, X.]] | ||
[[Category: Tardie, M.]] | [[Category: Tardie, M.]] | ||
| Line 25: | Line 24: | ||
[[Category: fatty acid binding protein]] | [[Category: fatty acid binding protein]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:43:45 2008'' |
Revision as of 15:43, 21 February 2008
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Crystal Structure of aP2
Overview
Human adipocyte lipid-binding protein (aP2) belongs to a family of intracellular lipid-binding proteins involved in the transport and storage of lipids. Here, the crystal structure of human aP2 with a bound palmitate is described at 1.5 A resolution. Unlike the known crystal structure of murine aP2 in complex with palmitate, this structure shows that the fatty acid is in a folded conformation and that the loop containing Phe57 acts as a lid to regulate ligand binding by excluding solvent exposure to the central binding cavity.
About this Structure
2HNX is a Single protein structure of sequence from Homo sapiens with , and as ligands. Full crystallographic information is available from OCA.
Reference
Expression, purification, crystallization and structure of human adipocyte lipid-binding protein (aP2)., Marr E, Tardie M, Carty M, Brown Phillips T, Wang IK, Soeller W, Qiu X, Karam G, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Nov 1;62(Pt, 11):1058-60. Epub 2006 Oct 25. PMID:17077479
Page seeded by OCA on Thu Feb 21 17:43:45 2008
Categories: Homo sapiens | Single protein | Carty, M. | Karam, G. | Marr, E. | Phillips, T Brown. | Qiu, X. | Tardie, M. | ACY | PLM | PO4 | Fatty acid binding protein
