3zpr
From Proteopedia
(Difference between revisions)
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==About this Structure== | ==About this Structure== | ||
[[3zpr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Meleagris_gallopavo Meleagris gallopavo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZPR OCA]. | [[3zpr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Meleagris_gallopavo Meleagris gallopavo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZPR OCA]. | ||
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| + | ==Reference== | ||
| + | <ref group="xtra">PMID:023517028</ref><references group="xtra"/><references/> | ||
[[Category: Meleagris gallopavo]] | [[Category: Meleagris gallopavo]] | ||
[[Category: Brown, J.]] | [[Category: Brown, J.]] | ||
Revision as of 06:32, 20 June 2013
Contents |
Thermostabilised turkey beta1 adrenergic receptor with 4-methyl-2-(piperazin-1-yl) quinoline bound
Template:ABSTRACT PUBMED 23517028
Function
[ADRB1_MELGA] Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity.
About this Structure
3zpr is a 2 chain structure with sequence from Meleagris gallopavo. Full crystallographic information is available from OCA.
Reference
- Christopher J, Brown J, Dore A, Errey J, Koglin M, Marshall FH, Myszka D, Rich RL, Tate CG, Tehan B, Warne T, Congreve M. Biophysical fragment screening of the beta1-adrenergic receptor: Identification of high affinity aryl piperazine leads using structure-based drug design. J Med Chem. 2013 Mar 21. PMID:23517028 doi:10.1021/jm400140q
