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4geb

From Proteopedia

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'''Unreleased structure'''
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{{STRUCTURE_4geb| PDB=4geb | SCENE= }}
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===Kynurenine Aminotransferase II Inhibitors===
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{{ABSTRACT_PUBMED_23466229}}
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The entry 4geb is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/AADAT_HUMAN AADAT_HUMAN]] Transaminase with broad substrate specificity. Has transaminase activity towards aminoadipate, kynurenine, methionine and glutamate. Shows activity also towards tryptophan, aspartate and hydroxykynurenine. Accepts a variety of oxo-acids as amino-group acceptors, with a preference for 2-oxoglutarate, 2-oxocaproic acid, phenylpyruvate and alpha-oxo-gamma-methiol butyric acid. Can also use glyoxylate as amino-group acceptor (in vitro).<ref>PMID:18620547</ref>
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Authors: Pandit, J.
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==About this Structure==
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[[4geb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GEB OCA].
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Description: Kynurenine Aminotransferase II Inhibitors
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==Reference==
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<ref group="xtra">PMID:023466229</ref><references group="xtra"/><references/>
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[[Category: Homo sapiens]]
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[[Category: Pandit, J.]]
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[[Category: Aminotransferase]]
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[[Category: Irreversible inhibitor]]
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[[Category: Transferase-transferase inhibitor complex]]

Revision as of 06:35, 20 June 2013

Template:STRUCTURE 4geb

Contents

Kynurenine Aminotransferase II Inhibitors

Template:ABSTRACT PUBMED 23466229

Function

[AADAT_HUMAN] Transaminase with broad substrate specificity. Has transaminase activity towards aminoadipate, kynurenine, methionine and glutamate. Shows activity also towards tryptophan, aspartate and hydroxykynurenine. Accepts a variety of oxo-acids as amino-group acceptors, with a preference for 2-oxoglutarate, 2-oxocaproic acid, phenylpyruvate and alpha-oxo-gamma-methiol butyric acid. Can also use glyoxylate as amino-group acceptor (in vitro).[1]

About this Structure

4geb is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Dounay AB, Anderson M, Bechle BM, Evrard E, Gan X, Kim JY, McAllister LA, Pandit J, Rong S, Salafia MA, Tuttle JB, Zawadzke LE, Verhoest PR. PF-04859989 as a template for structure-based drug design: Identification of new pyrazole series of irreversible KAT II inhibitors with improved lipophilic efficiency. Bioorg Med Chem Lett. 2013 Apr 1;23(7):1961-6. doi: 10.1016/j.bmcl.2013.02.039., Epub 2013 Feb 15. PMID:23466229 doi:10.1016/j.bmcl.2013.02.039
  1. ↑ Han Q, Cai T, Tagle DA, Robinson H, Li J. Substrate specificity and structure of human aminoadipate aminotransferase/kynurenine aminotransferase II. Biosci Rep. 2008 Aug;28(4):205-15. PMID:18620547 doi:10.1042/BSR20080085

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OCA

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