4gr8
From Proteopedia
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{{STRUCTURE_4gr8| PDB=4gr8 | SCENE= }} | {{STRUCTURE_4gr8| PDB=4gr8 | SCENE= }} | ||
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===Crystal structure of the catalytic domain of Human MMP12 in complex with selective phosphinic inhibitor RXP470C=== | ===Crystal structure of the catalytic domain of Human MMP12 in complex with selective phosphinic inhibitor RXP470C=== | ||
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{{ABSTRACT_PUBMED_23343195}} | {{ABSTRACT_PUBMED_23343195}} | ||
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| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/MMP12_HUMAN MMP12_HUMAN]] May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3. | ||
==About this Structure== | ==About this Structure== | ||
[[4gr8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GR8 OCA]. | [[4gr8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GR8 OCA]. | ||
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| + | ==Reference== | ||
| + | <ref group="xtra">PMID:023343195</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Macrophage elastase]] | [[Category: Macrophage elastase]] | ||
Revision as of 06:35, 20 June 2013
Contents |
Crystal structure of the catalytic domain of Human MMP12 in complex with selective phosphinic inhibitor RXP470C
Template:ABSTRACT PUBMED 23343195
Function
[MMP12_HUMAN] May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3.
About this Structure
4gr8 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Czarny B, Stura EA, Devel L, Vera L, Lajeunesse E, Beau F, Calderone V, Fragai M, Luchinat C, Dive V. Molecular determinants of a selective matrix metalloprotease-12 inhibitor: Insights from crystallography and thermodynamic studies. J Med Chem. 2013 Jan 23. PMID:23343195 doi:10.1021/jm301574d
