4kk2

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m (Protected "4kk2" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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{{STRUCTURE_4kk2| PDB=4kk2 | SCENE= }}
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===Crystal structure of a chimeric FPP/GFPP synthase (TARGET EFI-502313c) from Artemisia spiciformiS (1-72:GI751454468,73-346:GI75233326), apo structure===
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The entry 4kk2 is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/CHRDS_ARTSI CHRDS_ARTSI]] Condenses two molecules of dimethylallyl diphosphate (DMAPP) to produce mainly an irregular monoterpene, chrysanthemyl diphosphate (CPP) and lower amounts of a branched monoterpene, lavandulyl diphosphate (LPP). CPP is a precursor of the pyrethrin insecticides. When incubated with isopentenyl diphosphate (IPP) and DMAPP, catalyzes three competing isoprenoid condensation reactions, a chain elongation to give geranyl diphosphate (GPP), a cyclopropanation to give CPP and a branching to give LPP.<ref>PMID:12782626</ref>
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Authors: Vetting, M.W., Toro, R., Bhosle, R., Al Obaidi, N.F., Washington, E., Scott Glenn, A., Chowdhury, S., Evans, B., Hammonds, J., Hillerich, B., Love, J., Seidel, R.D., Imker, H.J., Poulter, C.D., Gerlt, J.A., Almo, S.C., Enzyme Function Initiative
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==About this Structure==
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[[4kk2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Artemisia_spiciformis Artemisia spiciformis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KK2 OCA].
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Description: Crystal structure of a chimeric FPP/GFPP synthase (TARGET EFI-502313c) from Artemisia spiciformiS (1-72:GI751454468,73-346:GI75233326), apo structure
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Artemisia spiciformis]]
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[[Category: Almo, S C.]]
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[[Category: Bhosle, R.]]
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[[Category: Chowdhury, S.]]
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[[Category: Evans, B.]]
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[[Category: Gerlt, J A.]]
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[[Category: Glenn, A Scott.]]
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[[Category: Hammonds, J.]]
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[[Category: Hillerich, B.]]
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[[Category: Imker, H J.]]
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[[Category: Initiative, Enzyme Function.]]
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[[Category: Love, J.]]
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[[Category: Obaidi, N F.Al.]]
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[[Category: Poulter, C D.]]
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[[Category: Seidel, R D.]]
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[[Category: Toro, R.]]
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[[Category: Vetting, M W.]]
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[[Category: Washington, E.]]
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[[Category: Enzyme function initiative]]
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[[Category: Isoprenoid synthase]]
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[[Category: Structural genomic]]
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[[Category: Transferase]]

Revision as of 07:27, 20 June 2013

Template:STRUCTURE 4kk2

Contents

Crystal structure of a chimeric FPP/GFPP synthase (TARGET EFI-502313c) from Artemisia spiciformiS (1-72:GI751454468,73-346:GI75233326), apo structure

Function

[CHRDS_ARTSI] Condenses two molecules of dimethylallyl diphosphate (DMAPP) to produce mainly an irregular monoterpene, chrysanthemyl diphosphate (CPP) and lower amounts of a branched monoterpene, lavandulyl diphosphate (LPP). CPP is a precursor of the pyrethrin insecticides. When incubated with isopentenyl diphosphate (IPP) and DMAPP, catalyzes three competing isoprenoid condensation reactions, a chain elongation to give geranyl diphosphate (GPP), a cyclopropanation to give CPP and a branching to give LPP.[1]

About this Structure

4kk2 is a 2 chain structure with sequence from Artemisia spiciformis. Full crystallographic information is available from OCA.

Reference

  1. ↑ Hemmerlin A, Rivera SB, Erickson HK, Poulter CD. Enzymes encoded by the farnesyl diphosphate synthase gene family in the Big Sagebrush Artemisia tridentata ssp. spiciformis. J Biol Chem. 2003 Aug 22;278(34):32132-40. Epub 2003 Jun 2. PMID:12782626 doi:10.1074/jbc.M213045200

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OCA

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