3qj4
From Proteopedia
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{{STRUCTURE_3qj4| PDB=3qj4 | SCENE= }} | {{STRUCTURE_3qj4| PDB=3qj4 | SCENE= }} | ||
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===Crystal structure of Human Renalase (isoform 1)=== | ===Crystal structure of Human Renalase (isoform 1)=== | ||
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{{ABSTRACT_PUBMED_21699903}} | {{ABSTRACT_PUBMED_21699903}} | ||
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| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/RNLS_HUMAN RNLS_HUMAN]] Probable FAD-dependent amine oxidase secreted by the kidney, which circulates in blood and modulates cardiac function and systemic blood pressure. Degrades catecholamines such as dopamine, norepinephrine and epinephrine in vitro. Lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular risk. High concentrations of catecholamines activate plasma renalase and promotes its secretion and synthesis (By similarity). According to PubMed:17385068, is unlikely that renalase has physiologically relevant catecholamine-oxidizing activity.<ref>PMID:15841207</ref> <ref>PMID:17385068</ref> | ||
==About this Structure== | ==About this Structure== | ||
[[3qj4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QJ4 OCA]. | [[3qj4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QJ4 OCA]. | ||
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| - | ==See Also== | ||
| - | *[[Monoamine oxidase|Monoamine oxidase]] | ||
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID:021699903</ref><references group="xtra"/> | + | <ref group="xtra">PMID:021699903</ref><references group="xtra"/><references/> |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Aliverti, A.]] | [[Category: Aliverti, A.]] | ||
Revision as of 07:37, 20 June 2013
Contents |
Crystal structure of Human Renalase (isoform 1)
Template:ABSTRACT PUBMED 21699903
Function
[RNLS_HUMAN] Probable FAD-dependent amine oxidase secreted by the kidney, which circulates in blood and modulates cardiac function and systemic blood pressure. Degrades catecholamines such as dopamine, norepinephrine and epinephrine in vitro. Lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular risk. High concentrations of catecholamines activate plasma renalase and promotes its secretion and synthesis (By similarity). According to PubMed:17385068, is unlikely that renalase has physiologically relevant catecholamine-oxidizing activity.[1] [2]
About this Structure
3qj4 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Milani M, Ciriello F, Baroni S, Pandini V, Canevari G, Bolognesi M, Aliverti A. FAD-Binding Site and NADP Reactivity in Human Renalase: A New Enzyme Involved in Blood Pressure Regulation. J Mol Biol. 2011 Jun 14. PMID:21699903 doi:10.1016/j.jmb.2011.06.010
- ↑ Xu J, Li G, Wang P, Velazquez H, Yao X, Li Y, Wu Y, Peixoto A, Crowley S, Desir GV. Renalase is a novel, soluble monoamine oxidase that regulates cardiac function and blood pressure. J Clin Invest. 2005 May;115(5):1275-80. Epub 2005 Apr 7. PMID:15841207 doi:10.1172/JCI24066
- ↑ Boomsma F, Tipton KF. Renalase, a catecholamine-metabolising enzyme? J Neural Transm. 2007;114(6):775-6. Epub 2007 Mar 26. PMID:17385068 doi:10.1007/s00702-007-0672-1
