2hr9
From Proteopedia
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==Overview== | ==Overview== | ||
| - | Human translationally controlled tumor protein (TCTP) is a growth-related, calcium-binding protein. We determined the solution structure and backbone | + | Human translationally controlled tumor protein (TCTP) is a growth-related, calcium-binding protein. We determined the solution structure and backbone dynamics of human TCTP, and identified the calcium-binding site of human TCTP using multi-dimensional NMR spectroscopy. The overall structure of human TCTP has a rather rigid well-folded core and a very flexible long loop connected by a short two-strand beta-sheet, which shows a conserved fold in the TCTP family. The C-terminal portions of loop L(alpha3beta8) and strand beta9 and the N-terminal region of strand beta8 may form a calcium-binding site in the human TCTP structure, which is largely conserved in the sequence alignment of TCTPs. The K(d) value for the calcium binding is 0.022-0.025 M indicating a very weak calcium-binding site. |
==About this Structure== | ==About this Structure== | ||
| - | 2HR9 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure | + | 2HR9 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry 1Y41. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HR9 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: tumor protein]] | [[Category: tumor protein]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:44:57 2008'' |
Revision as of 15:45, 21 February 2008
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Solution structure of human translationally controlled tumor protein
Overview
Human translationally controlled tumor protein (TCTP) is a growth-related, calcium-binding protein. We determined the solution structure and backbone dynamics of human TCTP, and identified the calcium-binding site of human TCTP using multi-dimensional NMR spectroscopy. The overall structure of human TCTP has a rather rigid well-folded core and a very flexible long loop connected by a short two-strand beta-sheet, which shows a conserved fold in the TCTP family. The C-terminal portions of loop L(alpha3beta8) and strand beta9 and the N-terminal region of strand beta8 may form a calcium-binding site in the human TCTP structure, which is largely conserved in the sequence alignment of TCTPs. The K(d) value for the calcium binding is 0.022-0.025 M indicating a very weak calcium-binding site.
About this Structure
2HR9 is a Single protein structure of sequence from Homo sapiens. This structure supersedes the now removed PDB entry 1Y41. Full crystallographic information is available from OCA.
Reference
Solution structure and mapping of a very weak calcium-binding site of human translationally controlled tumor protein by NMR., Feng Y, Liu D, Yao H, Wang J, Arch Biochem Biophys. 2007 Nov 1;467(1):48-57. Epub 2007 Aug 30. PMID:17897616
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