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Tumor necrosis factor
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'''Tumor necrosis factor''' (TNF) is a cytokine which can cause apoptosis. TNFα is implicated in tumor regression, septic shock, inflammation and cachexia (wasting syndrome). It is involved in the regulation of the immune cells. TNF is a transmembrane homotrimer. The soluble TNF is produced by cleavage by the metalloprotease TNF alpha converting enzyme (TACE or ADAM17 see [[A Disintegrin And Metalloproteinase]]). | '''Tumor necrosis factor''' (TNF) is a cytokine which can cause apoptosis. TNFα is implicated in tumor regression, septic shock, inflammation and cachexia (wasting syndrome). It is involved in the regulation of the immune cells. TNF is a transmembrane homotrimer. The soluble TNF is produced by cleavage by the metalloprotease TNF alpha converting enzyme (TACE or ADAM17 see [[A Disintegrin And Metalloproteinase]]). | ||
Revision as of 11:29, 24 June 2013
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