CD3 (or Cluster of Differentiation 3) is a T-cell co-receptor. The CD3 is composed of γ, δ and two ε chains. These 4 chains associate with the T-cell receptor (TCR) and a ζ chain to form an activation signal in T lymphocytes. CD3 assembles as 3 pairs of dimers: εγ, εδ and ζζ. The intracellular domain of CD3 contains a single immunorecetor tyrosine-based activation motif (ITAM). Drugs which bind to CD3 are tested as immunorepressants.
3D structures of CD3
Updated on 27-June-2013
CD2 ε chain
1a81 – hCD2 ITAM + Syk kinase – human
2k4f – mCD2 ITAM – mouse - NMR
3r08 – mCD2 extracellular domain + antibody
CD2 εγ dimer
1jbj – hCD2 extracellular domain - NMR
1sy6 – hCD2 extracellular domain + antibody
CD2 εδ dimer
1xiw – hCD2 extracellular domain + antibody
1xmw – mCD2 extracellular domain ε/sCD2 extracellular domain δ – sheep
CD2 ζ chain
1ygr, 2oq1 – hCD2 ITAM + CD45 protein tyrosine phosphatase
3ik5, 3ioz – hCD2 ITAM + NEF
2hac – hCD2 transmembrane domain - NMR
